product summary
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company name :
MyBioSource
product type :
antibody
product name :
RABBIT ANTI HUMAN DEFENSIN BETA 1
catalog :
MBS224033
quantity :
0.1 mg
price :
540 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS224033
products type :
Antibody
products full name :
RABBIT ANTI HUMAN DEFENSIN BETA 1
products short name :
DEFENSIN BETA 1
other names :
beta-defensin 1 preproprotein; Beta-defensin 1; beta-defensin 1; BD-1; beta defensin 1; beta-defensin-1; defensin, beta 1; Defensin, beta 1
other gene names :
DEFB1; DEFB1; BD1; HBD1; DEFB-1; DEFB101; BD1; HBD1; BD-1; hBD-1
uniprot entry name :
DEFB1_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
sequence length :
68
form :
Purified. Purified IgG - lyophilised
concentration :
IgG concentration 1.0mg/ml after reconstitution
storage stability :
Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of reconstitution.
tested application :
ELISA (EIA), Immunohistology Paraffin*, Western Blot (WB)
app notes :
ELISA: This purified human defensinbeta-1 antibody may be used in an indirect ELISA or as the capture reagent in a sandwich ELISA with our biotinylated human defensinbeta-1 antibody as the detection reagent and recombinant human defensinbeta-1 as the standard. ELISA: Minimum Dilution: 0.5; Maximum Dilution: 2.0ug/ml. Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. . Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml
other info1 :
Reconstitution: Reconstitute with 0.1ml distilled water Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For long term storage the addition of 0.09% sodium azide is recommended.
other info2 :
Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antiserum to human defensin beta 1 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography. Target Species: Human
products description :
Rabbit anti Human defensinbeta-1 polyclonal antibody recognizes human defensin beta 1 (BD-1), a secreted cationic antimicrobial peptide and member of the beta-defensin family, expressed at epithelial surfaces, which plays an important role in innate immunity. Studies by Goldman et al. have shown that the activity of BD-1 is compromised in patients with Cystic Fibrosis due to salt-dependent inactivation.
ncbi gi num :
4885181
ncbi acc num :
NP_005209.1
ncbi gb acc num :
NM_005218.3
uniprot acc num :
P60022
ncbi mol weight :
7,420 Da
ncbi pathways :
Beta Defensins Pathway (530759); Defensins Pathway (530757); Immune System Pathway (106386); Innate Immune System Pathway (106387)
ncbi summary :
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]
uniprot summary :
defensin, beta 1: Has bactericidal activity. Belongs to the beta-defensin family. Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 8p23.1. Cellular Component: extracellular space; Golgi lumen; extracellular region. Biological Process: G-protein coupled receptor protein signaling pathway; defense response to Gram-positive bacterium; innate immune response in mucosa; response to bacterium; antibacterial humoral response; innate immune response; immune response; response to testosterone stimulus; chemotaxis; acute inflammatory response
size1 :
0.1 mg
price1 :
540 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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