RABBIT ANTI HUMAN CXCL9 | MyBioSource MBS223923 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI HUMAN CXCL9

catalog :

MBS223923

quantity :

0.1 mg

price :

540 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS223923

products type :

Antibody

products full name :

RABBIT ANTI HUMAN CXCL9

products short name :

CXCL9

other names :

C-X-C motif chemokine 9; C-X-C motif chemokine 9; C-X-C motif chemokine 9; gamma-interferon-induced monokine; monokine induced by gamma interferon; monokine induced by interferon-gamma; small-inducible cytokine B9; chemokine (C-X-C motif) ligand 9; Gamma-interferon-induced monokine; Monokine induced by interferon-gamma; HuMIG; MIG; Small-inducible cytokine B9

products gene name :

CXCL9

other gene names :

CXCL9; CXCL9; CMK; MIG; Humig; SCYB9; crg-10; CMK; MIG; SCYB9; HuMIG; MIG

uniprot entry name :

CXCL9_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

sequence length :

125

form :

Purified. Purified IgG - lyophilised

concentration :

IgG concentration 1.0mg/ml after reconstitution

storage stability :

Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of reconstitution.

tested application :

ELISA (EIA), Functional Assays (FN), Immunohistology Paraffin, Western Blot (WB)

app notes :

ELISA: Minimum Dilution: 0.5; Maximum Dilution: 2.0ug/ml;. Functional Assays: Minimum Dilution: 5.0; Maximum Dilution: 7.0ug/ml;. Immunohistology - Paraffin. Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. . Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml

other info1 :

Reconstitution: Reconstitute with 0.1ml distilled water Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For long term storage the addition of 0.09% sodium azide is recommended.

other info2 :

Immunogen: Recombinant human CXCL9. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antiserum to human CXCL9 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. Target Species: Human

products description :

Rabbit anti Human CXCL9 polyclonal antinbody recognizes human CXCL9, otherwise known as MIG (monokine induced by Interferon-gamma), a member of the CXC family of chemokine receptors, secreted by interferon stimulated monocytes, macrophages (Muller et al. 2010) and endothelial cells (Loos et al. 2006) CXCL9 signals through binding to CD183 (CXCR3). CXCL9 acts as a Th1 (type 1 helper T) cell chemoattractant, and plays a role in the growth, activation and movement of cells associated with immune and inflammatory responses, and in tumour growth inhibition and angiogenesis (Whiting et al. 2004). Studies have shown that CXCL9 is active against E Coli, S.aureus, L.monocytogenes (Cole et al. 2001) and S.pyogenes (Egesten et al. 2007).

ncbi gi num :

4505187

ncbi acc num :

NP_002407.1

ncbi gb acc num :

NM_002416.2

uniprot acc num :

Q07325

ncbi mol weight :

14,019 Da

ncbi pathways :

CXCR3-mediated Signaling Events Pathway (138011); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (i) Signalling Events Pathway (119550)

ncbi summary :

This antimicrobial gene encodes a protein thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Sep 2014]

uniprot summary :

CXCL9: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family. Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 4q21. Cellular Component: extracellular space; extracellular region; external side of plasma membrane. Molecular Function: protein binding; CXCR3 chemokine receptor binding; chemokine activity; cytokine activity. Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; cellular defense response; defense response; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; immune response; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of cAMP metabolic process; chemotaxis; inflammatory response; signal transduction; defense response to virus; positive regulation of myoblast differentiation; regulation of cell proliferation

size1 :

0.1 mg

price1 :

540 USD

more info or order :

MyBioSource product webpage