RABBIT ANTI RAT NMDA RECEPTOR NR2A (N-TERMINAL) | MyBioSource MBS223862 product information

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product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI RAT NMDA RECEPTOR NR2A (N-TERMINAL)

catalog :

MBS223862

quantity :

0.1 mL

price :

635 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat, dog

application :

western blot

product information

catalog number :

MBS223862

products type :

Antibody

products full name :

RABBIT ANTI RAT NMDA RECEPTOR NR2A (N-TERMINAL)

products short name :

NMDAR NR2A

other names :

glutamate receptor ionotropic, NMDA 2A; Glutamate receptor ionotropic, NMDA 2A; glutamate receptor ionotropic, NMDA 2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor subunit 2A; glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A

products gene name :

NMDA

other gene names :

Grin2a; Grin2a; NR2A; GluN2A; NMDAR2A; GluN2A; NMDAR2A; NR2A

uniprot entry name :

NMDE1_RAT

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Bovine (Expected from Sequence), Dog (Expected from Sequence), Mouse (Expected from Sequence)

sequence length :

1464

specificity :

This item recognises the NR2A subunit of the NMDA (N-methyl-D-aspartate) receptor. Receptors for NMDA belong to a group of ionotropic glutamate receptors which play a key role in the mediation of glutamate neurotransmission within the mammalian central nervous system (CNS), including involvement in memory and learning processes. Several antagonists and agonists of NMDA receptors (NMDAR) have been identified. Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage-dependent Mg2+ blockade and high Ca2+permeability. The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimer's disease and also epilepsy and ischemic neuronal cell death.

form :

Purified. Purified IgG - liquid

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Western Blot (WB)

app notes :

Western Blot: This item detects a band of approximately 180kDa in rat hippocampal cell lysates. Western Blotting: Maximum Dilution: 1/1000

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3). 0.01% Bovine Serum Albumin. 50% Glycerol

other info2 :

Immunogen: Peptide from the N-terminus of the NR2A subunit of rat NMDA receptor. Buffer Solution: 10mM Hepes pH7.5, 150mM NaCl. Antiserum Preparation: Antisera to rat NMDA receptor NR2A subunit were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography. Target Species: Rat

products description :

MBS223862 recognises the NR2A subunit of the NMDA (N-methyl-D-aspartate) receptor. Receptors for NMDA belong to a group of ionotropic glutamate receptors which play a key role in the mediation of glutamate neurotransmission within the mammalian central nervous system (CNS), including involvement in memory and learning processes. Several antagonists and agonists of NMDA receptors (NMDAR) have been identified. Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage-dependent Mg2+ blockade and high Ca2+permeability. The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimer's disease and also epilepsy and ischemic neuronal cell death.

ncbi gi num :

140971205

ncbi acc num :

NP_036705.3

ncbi gb acc num :

NM_012573.3

uniprot acc num :

Q00959

ncbi mol weight :

165,469 Da

ncbi pathways :

Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (1121188); Alcoholism Pathway (585585); Alcoholism Pathway (587116); Alzheimer's Disease Pathway (83489); Alzheimer's Disease Pathway (509); Amphetamine Addiction Pathway (547642); Amphetamine Addiction Pathway (550546); Amyotrophic Lateral Sclerosis (ALS) Pathway (83491); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); CREB Phosphorylation Through The Activation Of CaMKII Pathway (1121195)

ncbi summary :

may play a role in synaptic transmission, learning and memory [RGD, Feb 2006]

uniprot summary :

NMDAR2A: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral. Cellular Component: presynaptic membrane; postsynaptic membrane; synaptic vesicle; neuron projection; cell surface; membrane; endoplasmic reticulum; postsynaptic density; dendritic spine; terminal button; synapse; cell junction; N-methyl-D-aspartate selective glutamate receptor complex. Molecular Function: voltage-gated cation channel activity; protein dimerization activity; neurotransmitter binding; glutamate receptor binding; zinc ion binding; calcium channel activity; protein kinase binding; ATPase binding; protein binding; extracellular-glutamate-gated ion channel activity; glutamate binding; protein heterodimerization activity; ionotropic glutamate receptor activity; N-methyl-D-aspartate selective glutamate receptor activity; protein complex binding; cation channel activity; cell adhesion molecule binding; receptor binding. Biological Process: regulation of long-term neuronal synaptic plasticity; startle response; positive regulation of apoptosis; rhythmic process; regulation of synaptic plasticity; response to other organism; sensory perception of pain; response to organic cyclic substance; dopamine metabolic process; response to carbohydrate stimulus; synaptic transmission; protein localization; learning and/or memory; calcium ion transport; response to methylmercury; response to wounding; visual learning; locomotion; protein tetramerization; cation transport; serotonin metabolic process; regulation of synaptic transmission; response to drug; response to light stimulus; regulation of action potential; synaptic transmission, glutamatergic; hippocampus development; response to amphetamine; learning; response to cocaine; sleep; memory; response to manganese ion; detection of mechanical stimulus involved in sensory perception of pain; regulation of membrane potential; regulation of postsynaptic membrane potential; response to ethanol; neurogenesis; spinal cord development; directional locomotion; ionotropic glutamate receptor signaling pathway; regulation of sensory perception of pain; cerebral cortex development; response to calcium ion; regulation of excitatory postsynaptic membrane potential; negative regulation of protein catabolic process; response to amine stimulus

size1 :

0.1 mL

price1 :

635 USD