GOAT ANTI HUMAN PPAR DELTA (C-TERMINAL) | MyBioSource MBS223130 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

GOAT ANTI HUMAN PPAR DELTA (C-TERMINAL)

catalog :

MBS223130

quantity :

0.1 mg

price :

515 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, chicken

application :

western blot, ELISA, enzyme immunoassay

product information

catalog number :

MBS223130

products type :

Antibody

products full name :

GOAT ANTI HUMAN PPAR DELTA (C-TERMINAL)

products short name :

PPAR DELTA

other names :

peroxisome proliferator-activated receptor delta isoform 1; Peroxisome proliferator-activated receptor delta; peroxisome proliferator-activated receptor delta; PPAR-beta; PPAR-delta; nuclear hormone receptor 1; nuclear receptor subfamily 1 group C member 2; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; peroxisome proliferator-activated receptor beta; peroxisome proliferator-activated receptor delta; NUCI; Nuclear hormone receptor 1; NUC1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferator-activated receptor beta; PPAR-beta

products gene name :

PPAR DELTA

other gene names :

PPARD; PPARD; FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB; NR1C2; PPARB; PPAR-delta; NUC1; PPAR-beta

uniprot entry name :

PPARD_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Goat

reactivity :

Chicken (Expected from Sequence), Mouse (Expected from Sequence), Pig (Expected from Sequence), Rat (Expected from Sequence)

sequence length :

343

specificity :

This item specifically recognises an epitope within the C-terminal (CT) region of isoform 1 of human PPAR delta (peroxisome proliferator-activated receptor delta), a ubiquitously expressed member of the nuclear hormone receptor subfamily of transcription factors, which regulates peroxisome numbers and influences fatty acid metabolism. The transcriptional activity of PPAR delta depends upon its interaction with retinoid X receptor (RXR), which together bind to peroxisome proliferator-response elements (PPREs) within the promoter region of target genes, in the presence of cofactors. The interaction of PPAR delta with NCoR (nuclear receptor corepressor) and SMRT (silencing mediator for retinoid and thyroid hormone receptor), results in repression of PPAR delta transactivation.

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 0.5mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

Western Blot: This item detects a band of approximately 50kDa in Jurkat Tcell lysates. ELISA: Maximum Dilution: 1/16000. Western Blotting: Minimum Dilution: 0.3; Maximum Dilution: 1.0ug/ml

other info1 :

Perservative Stabilisers: 0.02% Sodium Azide (NaN3). 0.5% Bovine Serum Albumin

other info2 :

Immunogen: Peptide sequence CHPLLQEIYKDMY corresponding to the C-Terminal region of PPAR delta (NP_006229.1). Buffer Solution: TRIS buffered saline. Antiserum Preparation: Antiserum to human PPAR Delta (CT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. Target Species: Human

products description :

MBS223130 specifically recognises an epitope within the C-terminal (CT) region of isoform 1 of human PPAR delta (peroxisome proliferator-activated receptor delta), a ubiquitously expressed member of the nuclear hormone receptor subfamily of transcription factors, which regulates peroxisome numbers and influences fatty acid metabolism. The transcriptional activity of PPAR delta depends upon its interaction with retinoid X receptor (RXR), which together bind to peroxisome proliferator-response elements (PPREs) within the promoter region of target genes, in the presence of cofactors. The interaction of PPAR delta with NCoR (nuclear receptor corepressor) and SMRT (silencing mediator for retinoid and thyroid hormone receptor), results in repression of PPAR delta transactivation.

ncbi gi num :

284807155

ncbi acc num :

NP_001165289.1

ncbi gb acc num :

NM_001171818.1

uniprot acc num :

Q03181

ncbi mol weight :

38,855 Da

ncbi pathways :

Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Adipogenesis Pathway 198832!!Energy Metabolism Pathway 198907!!Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway 160977!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!Import Of Palmitoyl-CoA Into The Mitochondrial Matrix Pathway 106108!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976

ncbi summary :

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

size :

0.1 mg

price :

515 USD