GOAT ANTI HUMAN Hsc70 | MyBioSource MBS223124 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

GOAT ANTI HUMAN Hsc70

catalog :

MBS223124

quantity :

0.1 mg

price :

500 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

western blot, ELISA, enzyme immunoassay

product information

catalog number :

MBS223124

products type :

Antibody

products full name :

GOAT ANTI HUMAN Hsc70

products short name :

Hsc70

other names :

heat shock cognate 71 kDa protein isoform 1; Heat shock cognate 71 kDa protein; heat shock cognate 71 kDa protein; LPS-associated protein 1; N-myristoyltransferase inhibitor protein 71; constitutive heat shock protein 70; epididymis luminal protein 33; epididymis secretory sperm binding protein Li 72p; heat shock 70kd protein 10; heat shock cognate protein 54; lipopolysaccharide-associated protein 1; heat shock 70kDa protein 8; Heat shock 70 kDa protein 8; Lipopolysaccharide-associated protein 1; LAP-1; LPS-associated protein 1

products gene name :

Hsc70

other gene names :

HSPA8; HSPA8; LAP1; HSC54; HSC70; HSC71; HSP71; HSP73; LAP-1; NIP71; HEL-33; HSPA10; HEL-S-72p; HSC70; HSP73; HSPA10; LAP-1; LPS-associated protein 1

uniprot entry name :

HSP7C_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Goat

reactivity :

Dog (Expected from Sequence), Mouse (Expected from Sequence), Rat (Expected from Sequence)

sequence length :

493

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 0.5mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

Western Blot: This product detects a band of approximately 75kDa in A431 cell lysates. ELISA: Maximum Dilution: 1/4000. Western Blotting: Minimum Dilution: 1.0; Maximum Dilution: 3.0ug/ml

other info1 :

Perservative Stabilisers: 0.02% Sodium Azide (NaN3). 0.5% Bovine Serum Albumin

other info2 :

Buffer Solution: Tris buffered saline. Antiserum Preparation: Antiserum to human Hsc70 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. Target Species: Human

products description :

Goat anti Human Hsc70 antibody recognizes human Heat shock cognate 71 kDa protein, also known as Heat shock 70 kDa protein 8 or Lipopolysaccharide-associated protein 1. Hsc70 is a 646 amino acid ubiquitously expressed cytoplasmic heat-shock cognate protein and member of the heat shock protein 70 family, encoded for by the HSPA8 gene. Goat anti Human Hsc70 antibody recognizes epitopes in the region between amino acids 555 and 570 of Hsc70 isoform 1, missing in isoform 2. Heat shock proteins are a group of constitutively expressed or heat/stress-inducible proteins which act as molecular chaperones and play an essential role in protein folding/unfolding and transport of proteins across membranes. Hsc70 facilitates the correct folding of newly-synthesized polypeptides (Flynn et al. 1989) and also participates in the ATPase disassociation of clathrin-coated vesicles during endocytosis, in conjunction with the co-chaperone auxilin (Jiang et al. 1997).

ncbi gi num :

5729877

ncbi acc num :

NP_006588.1

ncbi gb acc num :

NM_006597.5

uniprot acc num :

P11142

ncbi mol weight :

53,518 Da

ncbi pathways :

AUF1 (hnRNP D0) Destabilizes MRNA Pathway 187212!!Antigen Processing And Presentation Pathway 83074!!Antigen Processing And Presentation Pathway 485!!Attenuation Phase Pathway 1127556!!Axon Guidance Pathway 105688!!C-MYB Transcription Factor Network Pathway 138073!!CHL1 Interactions Pathway 161007!!Cellular Response To Heat Stress Pathway 1127553!!Cellular Responses To Stress Pathway 645258!!Clathrin Derived Vesicle Budding Pathway 119545

ncbi summary :

This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

size :

0.1 mg

price :

500 USD