product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
RABBIT ANTI ORAI3 (N-TERMINAL)
catalog :
MBS222947
quantity :
0.1 mg
price :
380 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot
more info or order :
product information
catalog number :
MBS222947
products type :
Antibody
products full name :
RABBIT ANTI ORAI3 (N-TERMINAL)
products short name :
ORAI3
other names :
protein orai-3; Protein orai-3; protein orai-3; transmembrane protein 142C; ORAI calcium release-activated calcium modulator 3; Transmembrane protein 142C
products gene name :
ORAI3
other gene names :
ORAI3; ORAI3; TMEM142C; TMEM142C
uniprot entry name :
ORAI3_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Mouse, Rat
sequence length :
295
specificity :
This item recognises human ORAI3, also known as Transmembrane protein 142C (TMEM142C), a 31.5 kDa multi-pass membrane protein belonging to the ORAI family. Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI3 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI3, along with ORAI1 and ORAI2, functions as a Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor. Studies indicate that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. This item is not expected to cross react with either ORAI1 or ORAI2.
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 1.0mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Immunohistology Frozen, Western Blot (WB)
app notes :
Western Blot: This item detects a band of approximately 35kDa in A20 cell lysates. Immunohistology - Frozen: Maximum Dilution: 10ug/ml. Western Blotting: Minimum Dilution: 1; Maximum Dilution: 2ug/ml
other info1 :
Perservative Stabilisers: 0.02% Sodium Azide (NaN3)
other info2 :
Immunogen: A 15 amino acid peptide from near the amino terminus of human ORAI3. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antiserum to human ORAI3 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. Target Species: Human
products description :
MBS222947 recognises human ORAI3, also known as Transmembrane protein 142C (TMEM142C), a 31.5 kDa multi-pass membrane protein belonging to the ORAI family. Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI3 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI3, along with ORAI1 and ORAI2, functions as a Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor. Studies indicate that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. MBS222947 is not expected to cross react with either ORAI1 or ORAI2.
ncbi gi num :
22748651
ncbi acc num :
NP_689501.1
ncbi gb acc num :
NM_152288.2
uniprot acc num :
Q9BRQ5
ncbi mol weight :
31,499 Da
ncbi pathways :
Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459)
uniprot summary :
TMEM142C: Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import. Belongs to the Orai family. Protein type: Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: integral to membrane. Molecular Function: protein binding
size1 :
0.1 mg
price1 :
380 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!