RABBIT ANTI HUMAN INTERLEUKIN-33 | MyBioSource MBS222931 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI HUMAN INTERLEUKIN-33

catalog :

MBS222931

quantity :

0.1 mg

price :

555 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS222931

products type :

Antibody

products full name :

RABBIT ANTI HUMAN INTERLEUKIN-33

products short name :

IL-33

other names :

interleukin-33 isoform 2; Interleukin-33; interleukin-33; DVS27-related protein; IL-1F11; IL-33; interleukin-1 family member 11; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules; interleukin 33; Interleukin-1 family member 11; IL-1F11; Nuclear factor from high endothelial venules; NF-HEV

other gene names :

IL33; IL33; DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26; C9orf26; IL1F11; NFHEV; IL-33; IL-1F11; NF-HEV

uniprot entry name :

IL33_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

sequence length :

228

form :

Purified. Purified IgG - lyophilised

concentration :

IgG concentration 1.0mg/ml

storage stability :

Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of reconstitution.

tested application :

ELISA (EIA), Immunohistology Paraffin*, Western Blot (WB)

app notes :

ELISA: Minimum Dilution: 0.5; Maximum Dilution: 2.0ug/ml;. Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. . Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml

other info1 :

Reconstitution: Reconstitute with 0.1ml distilled water For long term storage the addition of 0.09% sodium azide is recommended.

other info2 :

Immunogen: Recombinant human IL-33. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antiserum to human IL-33 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. Target Species: Human

products description :

Rabbit anti Human Interleukin-33 antibody recognizes human IL-33 (interleukin-33), formerly known as NF-HEV (nuclear factor from high endothelial venules), a recently described member of the IL-1 superfamily which signals through interaction with the ST2 and Toll-interleukin 1 (IL-1) receptors, and is known to act as an immunoregulator of T helper 2 (Th2) cell cytokine synthesis.

ncbi gi num :

313851030

ncbi acc num :

NP_001186569.1

ncbi gb acc num :

NM_001199640.1

uniprot acc num :

O95760

ncbi mol weight :

16,250 Da

ncbi pathways :

Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Influenza A Pathway (217173); Influenza A Pathway (217150)

ncbi summary :

IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011]

uniprot summary :

IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cytokine. Chromosomal Location of Human Ortholog: 9p24.1. Cellular Component: extracellular space; transport vesicle; chromosome; nucleus. Molecular Function: protein binding; cytokine activity. Biological Process: negative regulation of T-helper 1 type immune response; positive regulation of T-helper 2 type immune response; T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; negative regulation of leukocyte migration; positive regulation of interleukin-4 production; negative regulation of immunoglobulin secretion; negative regulation of interferon-gamma production; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of macrophage activation; positive regulation of inflammatory response

size1 :

0.1 mg

price1 :

555 USD

more info or order :

MyBioSource product webpage