GOAT ANTI HUMAN RAGE | MyBioSource MBS222435 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

GOAT ANTI HUMAN RAGE

catalog :

MBS222435

quantity :

0.1 ml

price :

405 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow, chimpanzee, Rhesus monkey

application :

western blot, ELISA, enzyme immunoassay

product information

catalog number :

MBS222435

products type :

Antibody

products full name :

GOAT ANTI HUMAN RAGE

products short name :

RAGE

other names :

advanced glycosylation end product-specific receptor isoform 1; Advanced glycosylation end product-specific receptor; advanced glycosylation end product-specific receptor; RAGE isoform NtRAGE-delta; RAGE isoform sRAGE-delta; receptor for advanced glycation end-products variant 20; advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products

products gene name :

RAGE

other gene names :

AGER; AGER; RAGE; RAGE

uniprot entry name :

RAGE_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Goat

reactivity :

Bovine (Expected from Sequence), Chimpanzee (Expected from Sequence), Dog, Mouse, Pig, Rabbit (Expected from Sequence), Rat, Rhesus Monkey (Expected from Sequence)

sequence length :

404

form :

Serum. Serum - liquid

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

ELISA (EIA), Functional Assays (FN)*, Immunohistology Paraffin*, Western Blot (WB)

app notes :

Western Blot: This item detects a band of approximately 45 kDa in mouse and rat lung lysates. ELISA: Minimum Dilution: 1/250K; Maximum Dilution: 1/270K. Functional Assays: Application Note: This product has been reported to have use in functional assays (Rodríguez-Ayala) however the product contains sodium azide, removal by dialysis is recommended prior to use in functional assays. Dialysis cassettes . Immunohistology - Paraffin: Minimum Dilution: 1/400; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. . Western Blotting: Minimum Dilution: 1/3000

other info1 :

Perservative Stabilisers: 0.1% Sodium Azide (NaN3)

other info2 :

Histology Positive Control Tissue: Diabetic kidney. Antiserum Preparation: Antisera to Human RAGE were raised by repeated immunisation of goats with highly purified antigen. Target Species: Human

products description :

Goat anti Human RAGE antibody recognises the human Advanced glycosylation end product-specific receptor, also known as Receptor for Advanced Glycation End products (RAGE). RAGE is a 404 amino acid ~45 kDa single pass type 1 transmembrane glycoprotein bearing two Ig-like C2-type and a single Ig-like V-type domain. RAGE is a member of the Immunoglobulin superfamily which binds a variety of ligands including advanced glycation end products (AGEs) and amyloid fibrils. RAGE is expressed by endothelium, mononuclear phagocytes, smooth muscle and neurons. RAGE may be involved in a range of pathological conditions including diabetes (Ndip et al. 2014) and Alzheimer's disease (Matrone et al. 2014).

ncbi gi num :

10835203

ncbi acc num :

NP_001127.1

ncbi gb acc num :

NM_001136.4

uniprot acc num :

Q15109

ncbi mol weight :

41,098 Da

ncbi pathways :

AGE/RAGE Pathway 698754!!Activated TLR4 Signalling Pathway 106400!!Advanced Glycosylation Endproduct Receptor Signaling Pathway 187092!!Cytosolic Sensors Of Pathogen-associated DNA Pathway 576255!!DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway 833822!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!MyD88 Cascade Initiated On Plasma Membrane Pathway 205107!!MyD88 Dependent Cascade Initiated On Endosome Pathway 187081!!MyD88-independent Cascade Pathway 106401

ncbi summary :

The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]

size :

0.1 ml

price :

405 USD