RABBIT ANTI LAMININ | MyBioSource MBS222395 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI LAMININ

catalog :

MBS222395

quantity :

0.25 ml

price :

415 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, dog, chicken

application :

ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS222395

products type :

Antibody

products full name :

RABBIT ANTI LAMININ

products short name :

LAMININ

other names :

Laminin; Laminin subunit gamma-2; laminin subunit gamma-2; BM600-100kDa; CSF 140 kDa subunit; cell-scattering factor 140 kDa subunit; epiligrin subunit gamma; kalinin subunit gamma; ladsin 140 kDa subunit; laminin B2t chain; large adhesive scatter factor 140 kDa subunit; nicein subunit gamma; laminin, gamma 2; Cell-scattering factor 140 kDa subunit; CSF 140 kDa subunit; Epiligrin subunit gamma; Kalinin subunit gamma; Kalinin/nicein/epiligrin 100 kDa subunit; Ladsin 140 kDa subunit; Laminin B2t chain; Laminin-5 subunit gamma; Large adhesive scatter factor 140 kDa subunit; Nicein subunit gamma

products gene name :

LAMININ

other gene names :

LAMC2; LAMC2; B2T; CSF; EBR2; BM600; EBR2A; LAMB2T; LAMNB2; LAMB2T; LAMNB2; CSF 140 kDa subunit

uniprot entry name :

LAMC2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Birds, Chicken, Dog, Duck, Human, Rabbit

sequence length :

1193

form :

Serum. Whole serum - liquid

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen, ELISA (EIA), Immunofluorescence (IF), Immunohistology Paraffin

app notes :

Immunohistology - Frozen: Minimum Dilution: 1/200; Maximum Dilution: 1/1000;. ELISA: Maximum Dilution: >1/1000

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide

other info2 :

Immunogen: Purified laminin from Engelbreth-Holm-Swarn (EHS). Histology Positive Control Tissue: Human kidney. Antiserum Preparation: Antisera to laminin were raised by repeated immunisation of rabbits with highly purified antigen.

products description :

Rabbit anti Laminin antibody recognizes both A (400kD) and B (220kD) chains of laminin.

ncbi gi num :

34230

ncbi acc num :

CAA78728.1

uniprot acc num :

Q13753

ncbi mol weight :

121,604 Da

ncbi pathways :

Alpha6-Beta4 Integrin Signaling Pathway 198807!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Anchoring Fibril Formation Pathway 730307!!Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway 730306!!Cell Junction Organization Pathway 160966!!Cell-Cell Communication Pathway 477132!!Collagen Formation Pathway 645288!!Degradation Of The Extracellular Matrix Pathway 576263!!ECM-receptor Interaction Pathway 83068

ncbi summary :

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq, Aug 2011]

size :

0.25 ml

price :

415 USD

more info or order :

MyBioSource product webpage