catalog number :
MBS222378
products full name :
RABBIT ANTI DYNORPHIN B (aa1-13)
products short name :
DYNORPHIN B
other names :
proenkephalin-B preproprotein; Proenkephalin-B; proenkephalin-B; beta-neoendorphin-dynorphin; preprodynorphin; Beta-neoendorphin-dynorphin; PreprodynorphinCleaved into the following 9 chains:Alpha-neoendorphin; Beta-neoendorphin; Big dynorphin; Big Dyn; Dynorphin A(1-17); Dyn-A17; Dynorphin A; Dynorphin A(1-13); Dynorphin A(1-8); Leu-enkephalin; RimorphinAlternative name(s):Dynorphin B; Dyn-B; Dynorphin B(1-13)
other gene names :
PDYN; PDYN; Big Dyn; Dyn-A17; Dynorphin A; Dyn-B
uniprot entry name :
PDYN_PIG
reactivity :
Bovine (Expected from Sequence), Chimpanzee (Expected from Sequence), Dog (Expected from Sequence), Gorilla (Expected from Sequence), Guinea Pig, Hamster, Horse (Expected from Sequence), Human (Expected from Sequence), Mouse (Expected from Sequence), Mous
form :
Serum. Serum - liquid
storage stability :
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Immunohistology Frozen, Radioimmunoassays (RIA)
app notes :
Immunohistology - Frozen: Minimum Dilution: 1/250; Maximum Dilution: 1/2500;. Radioimmunoassays: Maximum Dilution: 1/5000
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide. 1% Bovine Serum Albumin
other info2 :
Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to Dynorphin B (1-13) were raised by repeated immunisation of rabbits with highly purified antigen. Target Species: Pig
products description :
Rabbit anti Dynorphin B antibody recognizes dynorphin B, an endogenous opioid peptide, also known as rimorphin with the peptide sequence Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr, derived from the sequential cleavage of pro-enkephalin B to form leumorphin which is, in turn cleaved to form dynorphin B (Devi et al. 1985). The cleavage of the dynorphin precursors to form the dynorphin neuropeptides is largely controlled by the serine protease cathepsin L which co-localizes with dynorphins in secretory vesicles of brain cortical neurons(Funkelstein et al. 2010) and prohormone convertase 2, a member of the furin, peptidate S8 family (Schwarzer 2009). Dynorphin b sequence is well conserved among mammal, avian (Youngren et al. 1993) and reptilian (Goldsmith et al. 1992) species. Rabbit anti Dynorphin b antibody is expected to have a wide species cross reactivity.
ncbi acc num :
NP_001004040.1
ncbi gb acc num :
NM_001004040.1
ncbi mol weight :
28,617 Da
ncbi pathways :
Alcoholism Pathway 585587!!Alcoholism Pathway 587116!!Amphetamine Addiction Pathway 547650!!Amphetamine Addiction Pathway 550546!!Class A/1 (Rhodopsin-like Receptors) Pathway 1124655!!Cocaine Addiction Pathway 546272!!Cocaine Addiction Pathway 546273!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1124653!!Disease Pathway 1124325!!G Alpha (i) Signalling Events Pathway 1125294