RABBIT ANTI HUMAN OSTEOCALCIN | MyBioSource MBS222286 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI HUMAN OSTEOCALCIN

catalog :

MBS222286

quantity :

0.25 mL

price :

380 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, dog, cow

application :

immunohistochemistry, immunohistochemistry - frozen section

product information

catalog number :

MBS222286

products type :

Antibody

products full name :

RABBIT ANTI HUMAN OSTEOCALCIN

products short name :

OSTEOCALCIN

other names :

osteocalcin preproprotein; Osteocalcin; osteocalcin; bone Gla protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin); gamma-carboxyglutamic acid-containing protein; bone gamma-carboxyglutamate (gla) protein; Bone Gla protein; BGP; Gamma-carboxyglutamic acid-containing protein

other gene names :

BGLAP; BGLAP; OC; BGP; OCN; BGP

uniprot entry name :

OSTCN_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Bovine, Dog, Monkey

sequence length :

100

specificity :

This item is specific for intact osteocalcin and recognizes an epitope towards the C-terminal of the molecule. Osteocalcin (Bone Gla Protein) is a 49 amino acid single chain vitamin K dependent protein (MW 5.8 kDa), made by osteoblasts that is a major component of the non-collagenous bone matrix. Serum osteocalcin is elevated in diseases characterized by increased bone turnover such as osteoporosis, hyperparathyroidism and Paget's disease, and low in conditions associated with low bone turnover such as hypoparathyroidism and growth hormone deficiency.

form :

Serum. Serum - liquid

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen

app notes :

Immunohistology: This item is suitable for staining cultured human osteoblasts after fixation with 2% formaldehyde and permeabilization. Immunohistology - Frozen: Minimum Dilution: 1/25; Maximum Dilution: 1/50

other info1 :

Perservative Stabilisers: 0.1% Sodium Azide (NaN3)

other info2 :

Immunogen: Human osteocalcin. Target Species: Human

products description :

MBS222286 is specific for intact osteocalcin and recognizes an epitope towards the C-terminal of the molecule.Osteocalcin (Bone Gla Protein) is a 49 amino acid single chain vitamin K dependent protein (MW 5.8 kDa), made by osteoblasts that is a major component of the non-collagenous bone matrix. Serum osteocalcin is elevated in diseases characterized by increased bone turnover such as osteoporosis, hyperparathyroidism and Paget's disease, and low in conditions associated with low bone turnover such as hypoparathyroidism and growth hormone deficiency.

ncbi gi num :

40316933

ncbi acc num :

NP_954642.1

ncbi gb acc num :

NM_199173.4

uniprot acc num :

P02818

ncbi mol weight :

10,963 Da

ncbi pathways :

FGF Signaling Pathway (137989); Glucocorticoid Receptor Regulatory Network Pathway (138014); Interleukin-11 Signaling Pathway (698753); Notch-mediated HES/HEY Network Pathway (169347); Regulation Of Retinoblastoma Protein Pathway (137916); Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway (169349)

ncbi summary :

This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]

uniprot summary :

osteocalcin: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. Belongs to the osteocalcin/matrix Gla protein family. Protein type: Cell development/differentiation; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1q22. Cellular Component: Golgi apparatus; extracellular space; rough endoplasmic reticulum; dendrite; cytoplasm; perikaryon. Molecular Function: structural constituent of bone; hydroxyapatite binding; calcium ion binding; structural molecule activity. Biological Process: response to drug; response to gravity; regulation of bone resorption; response to glucocorticoid stimulus; cell aging; response to testosterone stimulus; bone mineralization; osteoblast development; osteoblast differentiation; odontogenesis; response to vitamin D; regulation of osteoclast differentiation; response to ethanol; response to vitamin K; response to estrogen stimulus; response to mechanical stimulus; response to zinc ion; response to hydroxyisoflavone; response to activity; cell adhesion; skeletal development; regulation of bone mineralization

size1 :

0.25 mL

price1 :

380 USD