catalog number :
MBS222075
products full name :
SHEEP ANTI HUMAN IgG3
products short name :
IgG3
other names :
Ig gamma-3 chain C region; Ig gamma-3 chain C region; immunoglobulin heavy constant gamma 3 (G3m marker); HDC; Heavy chain disease protein
products gene name :
IgG3
other gene names :
IGHG3; IGHG3; IgG3
uniprot entry name :
IGHG3_HUMAN
specificity :
This product recognizes Human IgG3.
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 1.0mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
ELISA: Minimum Dilution: 1/3000; Maximum Dilution: 1/6000;. Western Blotting: Minimum Dilution: 1/2500; Maximum Dilution: 1/5000
other info1 :
Perservative Stabilisers: 0.09 % Sodium Azide (NaN3). 0.1 % EACA. 0.01 % Benzamidine. 1 mM EDTA
other info2 :
Immunogen: Purified Human IgG3. Buffer Solution: Glycine buffered saline. Antiserum Preparation: Antisera prepared by immunisation of sheep with purified human IgG3. Purified IgG was prepared by affinity chromatography. Target Species: Human
products description :
This product recognizes Human IgG3.
ncbi mol weight :
41,287 Da
ncbi pathways :
Classical Antibody-mediated Complement Activation Pathway (106409); Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); FCGR Activation Pathway (771578); Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway (771577); IL4-mediated Signaling Events Pathway (137933); Immune System Pathway (106386); Initial Triggering Of Complement Pathway (106406); Innate Immune System Pathway (106387); Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway (771579)
uniprot summary :
IGHG3: Dimer linked by 12 disulfide bonds; it has an extra interchain disulfide bond at position 7 in addition to the 11 normally present in the hinge region. Chromosomal Location of Human Ortholog: 14q32.33. Cellular Component: extracellular space; extracellular region. Molecular Function: antigen binding. Biological Process: retinal homeostasis; innate immune response; complement activation, classical pathway; complement activation