GOAT ANTI HUMAN FERRITIN | MyBioSource MBS222010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

GOAT ANTI HUMAN FERRITIN

catalog :

MBS222010

quantity :

1 mg

price :

610 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

enzyme immunoassay

product information

catalog number :

MBS222010

products type :

Antibody

products full name :

GOAT ANTI HUMAN FERRITIN

products short name :

FERRITIN

other names :

ferritin light chain; Ferritin light chain; ferritin light chain; ferritin L subunit; ferritin L-chain; ferritin light polypeptide-like 3; ferritin, light polypeptide

other gene names :

FTL; FTL; LFTD; NBIA3; Ferritin L subunit

uniprot entry name :

FRIL_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Goat

sequence length :

175

specificity :

This item recognises human ferritin, a large globular protein found in the liver, intestines and spleen that functions as an iron storage complex. It consists of a mineral core of ferric oxide and a 24 subunit protein shell that assures solubility in an aqueous environment. This antibody recognises liver and spleen ferritin, but shows minimal reactivity with heart ferritin.

form :

Purified. Purified IgG - liquid

concentration :

Approximate Protein Concentration: 5.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

ELISA (EIA)

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography.

other info2 :

Immunogen: Human Liver Ferritin. Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

MBS222010 recognises human ferritin, a large globular protein found in the liver, intestines and spleen that functions as an iron storage complex. It consists of a mineral core of ferric oxide and a 24 subunit protein shell that assures solubility in an aqueous environment. This antibody recognises liver and spleen ferritin, but shows minimal reactivity with heart ferritin.

ncbi gi num :

20149498

ncbi acc num :

NP_000137.2

ncbi gb acc num :

NM_000146.3

ncbi mol weight :

20,020 Da

ncbi pathways :

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Clathrin Derived Vesicle Budding Pathway (119545); Golgi Associated Vesicle Biogenesis Pathway (119546); Integrated Pancreatic Cancer Pathway (711360); Iron Uptake And Transport Pathway (187191); Membrane Trafficking Pathway (106160); Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); Scavenging By Class A Receptors Pathway (833814); Transmembrane Transport Of Small Molecules Pathway (106572)

ncbi summary :

This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

uniprot summary :

FTL: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS). It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene. Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3); also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels. Belongs to the ferritin family. Protein type: Oxidoreductase. Chromosomal Location of Human Ortholog: 19q13.33. Cellular Component: ferritin complex; membrane; cytosol. Molecular Function: identical protein binding; protein binding; ferric iron binding; iron ion binding. Biological Process: receptor-mediated endocytosis; iron ion homeostasis; cellular iron ion homeostasis; post-Golgi vesicle-mediated transport; iron ion transport; transmembrane transport. Disease: Hyperferritinemia With Or Without Cataract; L-ferritin Deficiency; Neurodegeneration With Brain Iron Accumulation 3

size1 :

1 mg

price1 :

610 USD