This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
RABBIT ANTI AKT1 (N-TERMINAL)
catalog :
MBS221849
quantity :
0.1 mg
price :
320 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot
product information
catalog number :
MBS221849
products type :
Antibody
products full name :
RABBIT ANTI AKT1 (N-TERMINAL)
products short name :
AKT1
other names :
RAC-alpha serine/threonine-protein kinase; RAC-alpha serine/threonine-protein kinase; RAC-alpha serine/threonine-protein kinase; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-oncogene c-Akt; rac protein kinase alpha; v-akt murine thymoma viral oncogene homolog 1; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha
products gene name :
AKT1
other gene names :
AKT1; AKT1; AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA; PKB; RAC; PKB; PKB alpha
uniprot entry name :
AKT1_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Mouse, Rat
sequence length :
480
specificity :
This item recognises the N-terminal region of Akt1, a 48kDa protein kinase forming part of the PI3K-Akt signalling pathway, known to regulate cell growth, proliferation and survival. The PI3K-Akt1 pathway is negatively regulated by the tumour suppressor PTEN. Excessive Akt1 activation can lead to the formation of malignant tumours, and has been associated with prostate cancer progression.
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 1.0 mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Western Blot (WB)
app notes :
Western Blot: This item detects a band of approximately 48 kDa in human liver cell lysates. Western Blotting: Maximum Dilution: 1.0ug/ml
other info1 :
Perservative Stabilisers: 0.02% Sodium Azide
other info2 :
Immunogen: A 16 amino acid peptide located near the human Akt1 amino-terminus. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to human Akt1 (NT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. Target Species: Human
products description :
MBS221849 recognises the N-terminal region of Akt1, a 48kDa protein kinase forming part of the PI3K-Akt signalling pathway, known to regulate cell growth, proliferation and survival. The PI3K-Akt1 pathway is negatively regulated by the tumour suppressor PTEN. Excessive Akt1 activation can lead to the formation of malignant tumours, and has been associated with prostate cancer progression.
ncbi gi num :
62241013
ncbi acc num :
NP_001014431.1
ncbi gb acc num :
NM_001014431.1
uniprot acc num :
P31749
ncbi mol weight :
48,347 Da
ncbi pathways :
AGE/RAGE Pathway 698754!!AKT Phosphorylates Targets In The Cytosol Pathway 106475!!AKT Phosphorylates Targets In The Nucleus Pathway 106476!!AKT-mediated Inactivation Of FOXO1A Pathway 106333!!AMPK Signaling Pathway 198868!!AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Activation Of BAD And Translocation To Mitochondria Pathway 105659!!Activation Of BH3-only Proteins Pathway 105658!!Acute Myeloid Leukemia Pathway 83117
ncbi summary :
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
size :
0.1 mg
price :
320 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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