antibody

RABBIT ANTI GLYCINE RECEPTOR ALPHA 1/2 (N-TERMINAL)

MBS221817

0.2 mg

505 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

Antibody

RABBIT ANTI GLYCINE RECEPTOR ALPHA 1/2 (N-TERMINAL)

GLYCINE RECEPTOR ALPHA 1/2

glycine receptor subunit alpha-1; Glycine receptor subunit alpha-1; glycine receptor subunit alpha-1; glycine receptor 48 kDa subunit; glycine receptor strychnine-binding subunit; glycine receptor, alpha 1 subunit; glycine receptor, alpha 1; Glycine receptor 48 kDa subunit; Glycine receptor strychnine-binding subunit

Glra1; Glra1; GLYRA1; Glyr

GLRA1_RAT

Polyclonal

IgG

Rabbit

Human, Mouse

449

Purified. Purified IgG - lyophilised

Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of reconstitution.

Immunohistology Frozen, Western Blot (WB)

Western Blot: This item detects a band of approximately 48 kDa in rat spinal cord lysates. Immunohistology - Frozen: Maximum Dilution: 1/1000. Western Blotting: Maximum Dilution: 1/1000

Reconstitution: Reconstitute with 0.1 ml sterile PBS Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For long term storage the addition of 0.09% sodium azide is recommended.

Buffer Solution: Ammonium bicarbonate . Antiserum Preparation: Antisera to rat glycine receptor (NT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography. Target Species: Rat

Rabbit anti glycine receptor recognises an epitope within the N-terminal region (NT) of glycine receptor alpha 1 and alpha 2 subunits. Glycine receptors are members of the ligand-gated ion channel superfamily, which mediate fast inhibitory neurotransmission. The receptors are pentameric membrane proteins which form chloride channels. Binding of glycine to its receptor produces an increase in chloride conductance and membrane hyperpolarisation. Four genes encoding glycine receptor alpha subunits have been identified, together with a single beta polypeptide. Each subunit consists of a large extracellular N-terminal region, four transmembrane domains, and a large cytoplasmic domain.

6980950

NP_037265.1

NM_013133.1

51,686 Da

Ion Channel Transport Pathway (1121439); Ligand-gated Ion Channel Transport Pathway (1121441); Neuroactive Ligand-receptor Interaction Pathway (83445); Neuroactive Ligand-receptor Interaction Pathway (462); Transmembrane Transport Of Small Molecules Pathway (1121395)

glycine receptor strychnine binding subunit; generates glycine gated strychnine sensitive chloride current in the central nervous system [RGD, Feb 2006]

0.2 mg

505 USD