RABBIT ANTI HUMAN AURORA-A KINASE | MyBioSource MBS221764 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI HUMAN AURORA-A KINASE

catalog :

MBS221764

quantity :

0.05 mg

price :

405 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunoprecipitation

product information

catalog number :

MBS221764

products type :

Antibody

products full name :

RABBIT ANTI HUMAN AURORA-A KINASE

products short name :

AURORA-A KINASE

other names :

aurora kinase A; Aurora kinase A; aurora kinase A; ARK-1; Aurora-A kinase; IPL1-related kinase; aurora 2; aurora-related kinase 1; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; breast tumor-amplified kinase; breast-tumor-amplified kinase; hARK1; protein phosphatase 1, regulatory subunit 47; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine-protein kinase 15; serine/threonine-protein kinase 6; serine/threonine-protein kinase aurora-A; aurora kinase A; Aurora 2; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; hARK1; Breast tumor-amplified kinase; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A

other gene names :

AURKA; AURKA; AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; PPP1R47; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6; ARK-1; Aurora-related kinase 1; hARK1

uniprot entry name :

AURKA_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

sequence length :

403

specificity :

This item is specific for human Aurora A Kinase, also known as Serine/Threonine Kinase 6 (STK6). Aurora A Kinase is a cell-cycle regulated kinase that has an important role in centrosome maturation and chromosome segregation. This protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. Recent studies have revealed that Aurora A Kinase is frequently overexpressed in various human carcinomas, which would suggest that this protein may be involved in tumorigenesis.

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen, Immunoprecipitation (IP)

app notes :

Immunohistology - Frozen: Minimum Dilution: 1/250; Maximum Dilution: 1/1000;. Immunoprecipitation: Minimum Dilution: 2ug/mg protein; Maximum Dilution: 10ug/mg protein

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide

other info2 :

Immunogen: Synthetic peptide corresponding to a region of human Aurora A Kinase encoded within exon 5. Buffer Solution: TRIS-citrate/Phosphate buffered saline. Antiserum Preparation: Antisera to human Aurora A Kinase were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. Target Species: Human

products description :

MBS221764 is specific for human Aurora A Kinase, also known as Serine/Threonine Kinase 6 (STK6). Aurora A Kinase is a cell-cycle regulated kinase that has an important role in centrosome maturation and chromosome segregation. This protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. Recent studies have revealed that Aurora A Kinase is frequently overexpressed in various human carcinomas, which would suggest that this protein may be involved in tumorigenesis.

ncbi gi num :

38327562

ncbi acc num :

NP_003591.2

ncbi gb acc num :

NM_003600.2

uniprot acc num :

O14965

ncbi mol weight :

45,809 Da

ncbi pathways :

APC/C-mediated Degradation Of Cell Cycle Proteins Pathway (105825); APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway (105835); Aurora A Signaling Pathway (137925); Aurora B Signaling Pathway (138080); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); G2/M Transition Pathway (105801); Gastric Cancer Network 1 Pathway (760635); Integrated Breast Cancer Pathway (219801); Mitotic G2-G2/M Phases Pathway (160942)

ncbi summary :

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

AurA: a member of the AUR family of kinases. A cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines. Regulated by phosphorylation-dependent proteasomal degradation. Localized to mitotic centrosomes and spindle microtubules and is required for centrosome maturation. Loss of Aurora A leads to defective mitotic spindles and gross errors in chromosome segregation. Required for centrosome duplication and chromosome segregation. Overexpression in culture drives transformation and aneuploidy, and negatively regulates p53. Amplified or overexpressed in many tumors or cell lines. Found as a skin tumor susceptibility gene in mouse, and a human SNP in a degradation domain is weakly cancer-associated and undergoes allele-specific amplification. Inhibitors: VX-680, ZM447439, Hesperadin, SNS-595. Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; EC 2.7.11.1; Oncoprotein; Other group; AUR family. Chromosomal Location of Human Ortholog: 20q13. Cellular Component: germinal vesicle; centrosome; pronucleus; spindle pole centrosome; cytosol; axon hillock; microtubule cytoskeleton; spindle microtubule; perinuclear region of cytoplasm; spindle; midbody; spindle midzone; nucleus; condensed nuclear chromosome, pericentric region. Molecular Function: protein serine/threonine kinase activity; protein binding; ubiquitin protein ligase binding; protein serine/threonine/tyrosine kinase activity; histone serine kinase activity; protein kinase binding; ATP binding; protein kinase activity. Biological Process: spindle stabilization; mitosis; regulation of centrosome cycle; positive regulation of mitosis; protein amino acid autophosphorylation; regulation of protein stability; regulation of cytokinesis; protein amino acid phosphorylation; mitotic spindle organization and biogenesis; mitotic centrosome separation; centrosome localization; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of protein binding; spindle assembly involved in female meiosis I; negative regulation of apoptosis; anterior/posterior axis specification. Disease: Colorectal Cancer

size1 :

0.05 mg

price1 :

405 USD