RABBIT ANTI SARM1 | MyBioSource MBS221761 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI SARM1

catalog :

MBS221761

quantity :

0.1 mg

price :

360 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS221761

products type :

Antibody

products full name :

RABBIT ANTI SARM1

products short name :

SARM1

other names :

sterile alpha and TIR motif-containing protein 1; Sterile alpha and TIR motif-containing protein 1; sterile alpha and TIR motif-containing protein 1; SAM domain-containing protein 2; sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha motif domain-containing protein 2; tir-1 homolog; sterile alpha and TIR motif containing 1; Sterile alpha and Armadillo repeat protein; Sterile alpha motif domain-containing protein 2; MyD88-5; SAM domain-containing protein 2; Tir-1 homolog

products gene name :

SARM1

other gene names :

SARM1; SARM1; SARM; SAMD2; MyD88-5; KIAA0524; SAMD2; SARM; MyD88-5; SAM domain-containing protein 2

uniprot entry name :

SARM1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse

sequence length :

724

specificity :

This item is specific for human SARM1 (sterile alpha and TIR motif containing 1). SARM1 contains a Toll-interleukin-1 (TIR) domain, and is reported to serve as an adaptor protein for the Toll-like receptors during the innate immune response.

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Western Blot (WB)

app notes :

Western Blot: This item detects a band of approximately 80 kDa in Daudi cell lysates. Western Blotting: Minimum Dilution: 0.5ug/ml; Maximum Dilution: 2.0ug/ml

other info1 :

Perservative Stabilisers: 0.02% Sodium Azide

other info2 :

Immunogen: Synthetic peptide corresponding to a region within the C-Terminus of human SARM1. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to human SARM1 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography. Target Species: Human

products description :

MBS221761 is specific for human SARM1 (sterile alpha and TIR motif containing 1). SARM1 contains a Toll-interleukin-1 (TIR) domain, and is reported to serve as an adaptor protein for the Toll-like receptors during the innate immune response.

ncbi gi num :

154090976

ncbi acc num :

NP_055892.2

ncbi gb acc num :

NM_015077.3

uniprot acc num :

Q6SZW1

ncbi mol weight :

75,337 Da

ncbi pathways :

Activated TLR4 Signalling Pathway (106400); Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway (187088); IKK Complex Recruitment Mediated By RIP1 Pathway (187090); Immune System Pathway (106386); Innate Immune System Pathway (106387); MyD88-independent Cascade Pathway (106401); TRAF6 Mediated Induction Of TAK1 Complex Pathway (187091); TRIF-mediated TLR3/TLR4 Signaling Pathway (187089); Toll Like Receptor 3 (TLR3) Cascade Pathway (106391); Toll Like Receptor 4 (TLR4) Cascade Pathway (106398)

uniprot summary :

SARM1: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling. Negative regulator of NF- kappa-B and IRF activation. 2 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 17q11. Cellular Component: microtubule; mitochondrion; axon; cytoplasm; dendrite; extrinsic to mitochondrial outer membrane; synapse; cytosol; cell junction. Biological Process: regulation of apoptosis; MyD88-independent toll-like receptor signaling pathway; regulation of dendrite morphogenesis; toll-like receptor signaling pathway; response to glucose stimulus; innate immune response; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway

size1 :

0.1 mg

price1 :

360 USD

more info or order :

MyBioSource product webpage