RABBIT ANTI RAT CALCITONIN RECEPTOR | MyBioSource MBS221657 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI RAT CALCITONIN RECEPTOR

catalog :

MBS221657

quantity :

0.1 mg

price :

640 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS221657

products type :

Antibody

products full name :

RABBIT ANTI RAT CALCITONIN RECEPTOR

products short name :

CALCITONIN RECEPTOR

other names :

calcitonin receptor isoform 1a; Calcitonin receptor; calcitonin receptor; C1A/C1B; CT-R; calcitonin receptor; C1A/C1B

other gene names :

Calcr; Calcr; CT-R

uniprot entry name :

CALCR_RAT

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Atlantic Stingray, Fish, Human, Mouse

sequence length :

496

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch.

tested application :

Immunohistology Frozen, ELISA (EIA), Immunofluorescence (IF), Immunohistology Paraffin*, Western Blot (WB)

app notes :

Immunohistology - Frozen: Minimum Dilution: 1/10; Maximum Dilution: 1/50;. ELISA: Maximum Dilution: 1/10,000;. Immunohistology - Paraffin: Minimum Dilution: 1/10; Maximum Dilution: 1/50; Application Note: The use of 4% paraformaldehyde fixation, rather than formalin fixation is recommended. A sensitive detection system is also recommended. e.g. A catalysed signal amplification system. . Western Blotting: Maximum Dilution: Reducing conditions

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide

other info2 :

Immunogen: Synthetic peptide derived from a C-terminal sequence of rat calcitonin receptor. Histology Positive Control Tissue: Kidney, cultured osteoclasts. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to calcitonin receptor were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography on Protein A. Target Species: Rat

products description :

Rabbit anti Rat Calcitonin Receptor antibody recognizes the calcitonin receptor in human, mouse and rat. The calcitonin receptor is a seven transmembrane domain cell surface protein which is coupled to G protein messenger systems. MBS221657 recognizes an epitope within the cytoplasmic domain that is common to both C1a and C1b rat isoforms. Calcitonin receptor is expressed in kidney, central and peripheral nervous systems and in osteoclasts. It is also expressed in a number of tissues during the development of the embryo and may be important in foetal morphogenesis.

ncbi gi num :

77404382

ncbi acc num :

NP_001029187.1

ncbi gb acc num :

NM_001034015.1

uniprot acc num :

P32214

ncbi mol weight :

55,879 Da

ncbi pathways :

Calcitonin-like Ligand Receptors Pathway (1120740); Class B/2 (Secretin Family Receptors) Pathway (1120739); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1122016); Disease Pathway (1121849); G Alpha (s) Signalling Events Pathway (1120744); GPCR Downstream Signaling Pathway (1120743); GPCR Ligand Binding Pathway (1120713); GPCRs, Class B Secretin-like Pathway (198460); Metabolic Disorders Of Biological Oxidation Enzymes Pathway (1121989); Neuroactive Ligand-receptor Interaction Pathway (83445)

ncbi summary :

receptor for calcitonin; acts via adenylate cyclase signaling [RGD, Feb 2006]

uniprot summary :

CALCR: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. Belongs to the G-protein coupled receptor 2 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 2; Receptor, GPCR. Cellular Component: neuron projection; cell soma; axon; integral to membrane; plasma membrane; acrosome; cytosol; cilium. Molecular Function: calcitonin binding; receptor activity; protein transporter activity; calcitonin receptor activity. Biological Process: regulation of bone resorption; response to glucocorticoid stimulus; adenylate cyclase activation; osteoclast differentiation; regulation of mRNA stability; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; protein transport; elevation of cytosolic calcium ion concentration; phospholipase C activation; receptor internalization; positive regulation of cAMP biosynthetic process; negative regulation of ossification; positive regulation of adenylate cyclase activity

size1 :

0.1 mg

price1 :

640 USD

more info or order :

MyBioSource product webpage