antibody

RABBIT ANTI HUMAN BCL-10 (aa5-19)

MBS221633

0.1 mg

320 USD

polyclonal

rabbit

nonconjugated

Antibody

RABBIT ANTI HUMAN BCL-10 (aa5-19)

Bcl-10

B-cell lymphoma/leukemia 10; B-cell lymphoma/leukemia 10; B-cell lymphoma/leukemia 10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CED-3/ICH-1 prodomain homologous E10-like regulator; cCARMEN; caspase-recruiting domain-containing protein; cellular homolog of vCARMEN; cellular-E10; hCLAP; mammalian CARD-containing adapter molecule E10; B-cell CLL/lymphoma 10; B-cell CLL/lymphoma 10; Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; hCLAP; CED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; Cellular homolog of vCARMEN; cCARMEN; Cellular-E10; c-E10; Mammalian CARD-containing adapter molecule E10; mE10

BCL-10

BCL10; BCL10; CLAP; mE10; CIPER; IMD37; c-E10; CARMEN; CIPER; CLAP; Bcl-10; hCLAP; CIPER; cCARMEN; c-E10; mE10

BCL10_HUMAN

Polyclonal

IgG

Rabbit

233

This item recognises Bcl-10 a CARD (caspase recruitment domain) containing protein involved in apoptosis. Bcl-10 is expressed in many human tissues and cell lines. Bcl-10 has been reported to exhibit mutations in MALT lymphomas and in lymphomas of B and T cell lineage.

Purified. Purified IgG - liquid

IgG concentration 0.5 mg/ml

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

Western Blot (WB)

Western Blotting: Maximum Dilution: 1/500

Perservative Stabilisers: 0.02% Sodium Azide

Immunogen: Peptide corresponding to amino acids 5 to 19 of human Bcl-10 (NT). Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to Bcl-10 (NT) were raised by repeated immunisation of rabbit with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. Target Species: Human

MBS221633 recognises Bcl-10 a CARD (caspase recruitment domain) containing protein involved in apoptosis. Bcl-10 is expressed in many human tissues and cell lines. Bcl-10 has been reported to exhibit mutations in MALT lymphomas and in lymphomas of B and T cell lineage.

4502379

NP_003912.1

NM_003921.4

O95999

26,252 Da

Activation Of NF-kappaB In B Cells Pathway 576251!!Adaptive Immune System Pathway 366160!!B Cell Receptor Signaling Pathway 198909!!B Cell Receptor Signaling Pathway 83081!!B Cell Receptor Signaling Pathway 492!!BCR Signaling Pathway 138058!!Canonical NF-kappaB Pathway 138030!!Downstream TCR Signaling Pathway 106418!!Downstream Signaling Events Of B Cell Receptor (BCR) Pathway 576250!!FCERI Mediated NF-kB Activation Pathway 833828

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]

0.1 mg

320 USD