catalog number :
MBS221623
products full name :
RABBIT ANTI HUMAN ACINUS
products short name :
ACINUS
other names :
apoptotic chromatin condensation inducer in the nucleus isoform 2; Apoptotic chromatin condensation inducer in the nucleus; apoptotic chromatin condensation inducer in the nucleus; functional spliceosome-associated protein 152; apoptotic chromatin condensation inducer 1
products gene name :
ACINUS
other gene names :
ACIN1; ACIN1; ACN; ACINUS; fSAP152; ACINUS; KIAA0670; Acinus
uniprot entry name :
ACINU_HUMAN
specificity :
This item recognises Acinus (apoptosis chromatin condensation inducer in the nucleus), an inducer of chromatin condensation. The antibody recognises three splice forms of Acinus designated Acinus L, Acinus S and Acinus S'.
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 0.5 mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Western Blot (WB)
app notes :
Western Blotting: Maximum Dilution: 1/500
other info1 :
Perservative Stabilisers: 0.02% Sodium Azide
other info2 :
Immunogen: Peptide DDPVRTAQVPSPPRGK corresponding to a region near the N-terminus of the active peptide p17. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to Acinus were raised by repeated immunisation of rabbit with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. Target Species: Human
products description :
MBS221623 recognises Acinus (apoptosis chromatin condensation inducer in the nucleus), an inducer of chromatin condensation. The antibody recognises three splice forms of Acinus designated Acinus L, Acinus S and Acinus S'.
ncbi acc num :
NP_001158286.1
ncbi gb acc num :
NM_001164814.1
ncbi mol weight :
150,557 Da
ncbi pathways :
Apoptosis Pathway 105648!!Apoptotic Cleavage Of Cellular Proteins Pathway 105678!!Apoptotic Execution Phase Pathway 105677!!Exon Junction Complex (EJC) Pathway 470353!!Exon Junction Complex (EJC) Pathway 890638!!Programmed Cell Death Pathway 1127510!!RNA Transport Pathway 177876!!RNA Transport Pathway 175229!!Spliceosome Pathway 125136!!Spliceosome Pathway 124832
ncbi summary :
Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]