RABBIT ANTI MOUSE CIDE-A (aa200-214) | MyBioSource MBS221604 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI MOUSE CIDE-A (aa200-214)

catalog :

MBS221604

quantity :

0.1 mg

price :

350 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS221604

products type :

Antibody

products full name :

RABBIT ANTI MOUSE CIDE-A (aa200-214)

products short name :

CIDE-A

other names :

cell death activator CIDE-A; Cell death activator CIDE-A; cell death activator CIDE-A; cell death-inducing DFFA-like effector A; cell death-inducing DNA fragmentation factor, alpha subunit-like effector A; Cell death-inducing DFFA-like effector A

products gene name :

CIDE-A

other gene names :

Cidea; Cidea; AW212747

uniprot entry name :

CIDEA_MOUSE

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

sequence length :

217

specificity :

This item recognises murine CIDE-A (cell death inducing DFF-like effector A) protein with homology to the N-terminal region of DFF45 (ICAD) CIDE-A expression has been reported to activate apoptosis in mammalian cells, which is inhibited by DFF45. This item recognises an epitope within the C terminal region of CIDE-A and does not cross react with CIDE-B.

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 0.5 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Paraffin*, Western Blot (WB)

app notes :

Immunohistology - Paraffin: Minimum Dilution: 1/100; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. . Western Blotting: Maximum Dilution: 1/500

other info1 :

Perservative Stabilisers: 0.02% Sodium Azide

other info2 :

Immunogen: Synthetic peptide corresponding to amino acids 200-214 of mouse CIDE-A. Histology Positive Control Tissue: Mouse heart. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to Murine CIDE-A were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography. Target Species: Mouse

products description :

MBS221604 recognises murine CIDE-A (cell death inducing DFF-like effector A) protein with homology to the N-terminal region of DFF45 (ICAD) CIDE-A expression has been reported to activate apoptosis in mammalian cells, which is inhibited by DFF45. MBS221604 recognises an epitope within the C terminal region of CIDE-A and does not cross react with CIDE-B.

ncbi gi num :

162287227

ncbi acc num :

NP_031728.2

ncbi gb acc num :

NM_007702.2

uniprot acc num :

O70302

ncbi mol weight :

24,669 Da

uniprot summary :

CIDEA: Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter. Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear. In omental and subcutaneous adipose tissue of obese patients matched for BMI, expression levels correlate with insulin sensitivity. Expression is increased 5-6 fold in the group of patients with high insulin sensitivity, compared to the insulin- resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle. Protein type: Mitochondrial; Apoptosis. Cellular Component: mitochondrial envelope; mitochondrion; cytoplasm; lipid particle; intracellular; nucleus. Molecular Function: protein binding; protein homodimerization activity. Biological Process: cell death; sequestering of lipid; transcription, DNA-dependent; negative regulation of lipid catabolic process; regulation of transcription, DNA-dependent; apoptosis; negative regulation of cytokine secretion; thermoregulation; negative regulation of tumor necrosis factor production; lipid metabolic process; negative regulation of transforming growth factor beta receptor signaling pathway

size1 :

0.1 mg

price1 :

350 USD

more info or order :

MyBioSource product webpage