catalog number :
MBS221592
products full name :
RABBIT ANTI MOUSE ICAD (C-TERMINAL)
products short name :
ICAD
other names :
DNA fragmentation factor subunit alpha isoform a; DNA fragmentation factor subunit alpha; DNA fragmentation factor subunit alpha; DNA fragmentation factor 45 kDa subunit; inhibitor of CAD; DNA fragmentation factor, alpha subunit; DNA fragmentation factor 45 kDa subunit; DFF-45; Inhibitor of CAD; ICAD
products gene name :
ICAD
other gene names :
Dffa; Dffa; ICAD; DFF35; Dff45; ICAD-L; ICAD-S; A330085O09Rik; Icad; DFF-45; ICAD
uniprot entry name :
DFFA_MOUSE
specificity :
ICAD (Inhibitor of Caspase-Activated DNase) is the murine homologue of human DFF-45. ICAD is cleaved by Caspase-3, releasing CAD which eventually causes degradation of DNA in the nucleus. This item recognises a 45kD band in Western blots.
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 0.5mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Western Blot (WB)
app notes :
Western Blotting: Minimum Dilution: 1/500; Maximum Dilution: 1/1000
other info1 :
Perservative Stabilisers: 0.02% Sodium Azide
other info2 :
Immunogen: Synthetic peptide corresponding to amino acids 312-331 of mouse ICAD. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to murine ICAD were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography. Target Species: Mouse
products description :
ICAD (Inhibitor of Caspase-Activated DNase) is the murine homologue of human DFF-45. ICAD is cleaved by Caspase-3, releasing CAD which eventually causes degradation of DNA in the nucleus. MBS221591 recognises a 45kD band in Western blots.
ncbi acc num :
NP_001020467.1
ncbi gb acc num :
NM_001025296.2
ncbi mol weight :
29,183 Da
ncbi pathways :
Activation Of DNA Fragmentation Factor Pathway 1111526!!Apoptosis Pathway 198339!!Apoptosis Pathway 83257!!Apoptosis Pathway 470!!Apoptosis Pathway 1111498!!Apoptosis Induced DNA Fragmentation Pathway 1111525!!Apoptosis Signaling Pathway 522973!!Apoptotic Execution Phase Pathway 1111520!!FAS Pathway And Stress Induction Of HSP Regulation 198421!!PluriNetWork Pathway 198307