antibody

RABBIT ANTI HUMAN CD49d (C-TERMINAL)

MBS221512

0.05 mg

685 USD

polyclonal

rabbit

nonconjugated

immunohistochemistry, immunohistochemistry - paraffin section

Antibody

RABBIT ANTI HUMAN CD49d (C-TERMINAL)

CD49d

integrin alpha-4; Integrin alpha-4; integrin alpha-4; 269C wild type; CD49 antigen-like family member D; VLA-4 subunit alpha; antigen CD49D, alpha-4 subunit of VLA-4 receptor; integrin alpha 4; integrin alpha-4 subunit; integrin alpha-IV; very late activation protein 4 receptor, alpha 4 subunit; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD_antigen: CD49d

CD49d

ITGA4; ITGA4; IA4; CD49D; CD49D

ITA4_HUMAN

Polyclonal

IgG

Rabbit

1032

Purified. Purified IgG - liquid

IgG concentration 1.0mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

Immunohistology Paraffin*

Immunohistology - Paraffin: Minimum Dilution: 15; Maximum Dilution: 25ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.

Perservative Stabilisers: 0.1% Sodium Azide (NaN3)

Histology Positive Control Tissue: Thymus, Medulla. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to human CD49d were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography. Target Species: Human

Rabbit anti Human CD49d polyclonal antibody detects an epitope within the C-terminal region of human CD49d, also known as integrin alpha-4 or VLA-4 subunit alpha. CD49d is a ~150kDa single pass type 1 transmembrane glycoprotein with seven FG-GAP repeats, characteristic of alpha integrins, in its extracellular domain. CD49d can be proteolytically cleaved to yield framents of 80 and 70kDa (Hemler et al. 1987). CD49d associates with either CD29 to form VLA-4 or with Integrin beta-7 to form The Peyer patches-specific homing receptor LPAM-1, involved in the lymphocyte migration and homing to gut-associated lymphoid tissue (Sackstein 2006) through its interaction with MadCam-1, preferentially expressed on Peyer's patch high endothelial venules and postcapillary venules in lamina propria (Briskin et al. 1997). VLA-4 is expressed on lymphocytes, monocytes, mast cells, macrophages, basophils and eosinophils, and has key roles in inflammation, cellular adhesion and cellular activation. LPAM-1 is expressed mainly on lymphocytes, and plays a key role in lymphocyte recruitment to sites of inflammation.

67191027

NP_000876.3

NM_000885.4

P13612

21,536 Da

Adaptive Immune System Pathway 366160!!Arrhythmogenic Right Ventricular Cardiomyopathy Pathway 672454!!Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 117293!!Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 116129!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480!!Cell Surface Interactions At The Vascular Wall Pathway 106062!!Dilated Cardiomyopathy Pathway 121494!!Dilated Cardiomyopathy Pathway 121285!!ECM-receptor Interaction Pathway 83068

The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008]

0.05 mg

685 USD