This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
RABBIT ANTI HUMAN xCT (N-TERMINAL)
catalog :
MBS221510
quantity :
0.05 mg
price :
705 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
immunohistochemistry, immunohistochemistry - paraffin section
product information
catalog number :
MBS221510
products type :
Antibody
products full name :
RABBIT ANTI HUMAN xCT (N-TERMINAL)
products short name :
xCT
other names :
cystine/glutamate transporter; Cystine/glutamate transporter; cystine/glutamate transporter; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrier family 7 member 11; solute carrier family 7, (cationic amino acid transporter, y+ system) member 11; solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT
products gene name :
xCT
other gene names :
SLC7A11; SLC7A11; xCT; CCBR1
uniprot entry name :
XCT_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
sequence length :
501
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 1.0mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Immunohistology Paraffin*
app notes :
Immunohistology - Paraffin: Minimum Dilution: 20; Maximum Dilution: 30ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
other info1 :
Perservative Stabilisers: 0.1% Sodium Azide (NaN3)
other info2 :
Histology Positive Control Tissue: Neurons or astrocytes. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to human xCT were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography. Target Species: Human
products description :
Rabbit anti human xCT (N-terminal) antibody detects an epitope within the N-terminal (NT) of the cysteine/glutamate transporter xCT, which forms a complex with the 4F2 heavy chain (CD98), via a disulfide bond. This heterodimer forms a Na+ independent amino acid transport system which leads to the uptake of extracellular L-cystine in conjunction to L-glutamate efflux. This system is thought to play an important role in the protection of neurons and activated macrophages against oxidative stress. xCT is the receptor which mediates Kaposi's sarcoma herpesvirus (KSHV) cell fusion.
ncbi gi num :
7657683
ncbi acc num :
NP_055146.1
ncbi gb acc num :
NM_014331.3
uniprot acc num :
Q9UPY5
ncbi mol weight :
55,423 Da
ncbi pathways :
Amino Acid Transport Across The Plasma Membrane Pathway 106170!!Basigin Interactions Pathway 106065!!Cell Surface Interactions At The Vascular Wall Pathway 106062!!Hemostasis Pathway 106028!!SLC-mediated Transmembrane Transport Pathway 119558!!Transmembrane Transport Of Small Molecules Pathway 106572!!Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway 119559
ncbi summary :
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
size :
0.05 mg
price :
705 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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