MyBioSource

antibody

GOAT ANTI HUMAN SDF-1 BETA

MBS221499

0.1 mg

555 USD

polyclonal

goat

human

enzyme immunoassay, ELISA, western blot

MBS221499

Antibody

GOAT ANTI HUMAN SDF-1 BETA

SDF-1 BETA

stromal cell-derived factor 1 isoform beta; Stromal cell-derived factor 1; stromal cell-derived factor 1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor; chemokine (C-X-C motif) ligand 12; C-X-C motif chemokine 12; Intercrine reduced in hepatomas; IRH; hIRH; Pre-B cell growth-stimulating factor; PBSF

SDF-1 BETA

CXCL12; CXCL12; IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12; SDF1; SDF1A; SDF1B; SDF-1; hSDF-1; IRH; hIRH; PBSF

SDF1_HUMAN

Polyclonal

IgG

Goat

93

Purified. Purified IgG - lyophilised

IgG concentration 1.0mg/ml

Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of reconstitution.

ELISA (EIA), Western Blot (WB)

ELISA: Maximum Dilution: 0.5ug/ml;. Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml

Reconstitution: Reconstitute with 0.1ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended.

Immunogen: Recombinant human SDF-1 beta. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to human SDF-1 beta were raised by repeated immunisations of goats with highly purified antigen. Purified IgG prepared by affinity chromatography. Target Species: Human

Goat anti Human SDF-1 beta antibody recognizes human SDF-1 beta, otherwise known as CXCL12b, a 72 amino acid stromal cell derived CXC chemokine, which arises from alternative splicing of the SDF-1 gene. The two isoforms, SDF-1 alpha and SDF-1 beta, share an identical amino acid sequence, except for an additional four residues in the C-Terminal region of the beta isoform. SDF-1 binds with high-affinity to the G protein -coupled receptor CXCR4 (fusin) and acts as a chemoattractant for T and B lymphocytes, monocytes and migratory neurons, and is a vital factor in haematopoiesis and angiogenesis. By competitively binding to CXCR4, SDF-1 acts as an inhibitor for the CXCR4-mediated entry of HIV-1 virus into target T-cells, and the SDF-1-CXCR4 interaction is important for the regulation of trafficking of normal and malignant stem cells.

10834988

NP_000600.1

NM_000609.6

P48061

11,004 Da

Axon Guidance Pathway 83065!!Axon Guidance Pathway 476!!CXCR4-mediated Signaling Events Pathway 137910!!Chemokine Receptors Bind Chemokines Pathway 106359!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664

This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

0.1 mg

555 USD