RABBIT ANTI TIM-1 | MyBioSource MBS221475 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI TIM-1

catalog :

MBS221475

quantity :

0.1 mg

price :

445 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS221475

products type :

Antibody

products full name :

RABBIT ANTI TIM-1

products short name :

TIM-1

other names :

hepatitis A virus cellular receptor 1; Hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1; T cell immunoglobin domain and mucin domain protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; kidney injury molecule 1; hepatitis A virus cellular receptor 1; Kidney injury molecule 1; KIM-1; T-cell immunoglobulin and mucin domain-containing protein 1; TIMD-1; T-cell immunoglobulin mucin receptor 1; TIM; TIM-1; T-cell membrane protein 1

products gene name :

TIM-1

other gene names :

HAVCR1; HAVCR1; TIM; KIM1; TIM1; HAVCR; KIM-1; TIM-1; TIMD1; TIMD-1; HAVCR-1; KIM1; TIM1; TIMD1; HAVcr-1; KIM-1; TIMD-1; TIM; TIM-1

uniprot entry name :

HAVR1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse, Rat

sequence length :

364

specificity :

This item detects T cell immunoglobulin mucin-1 (TIM-1), which was first identified as the receptor used by hepatitis A for viral entry (it is also known as the hepatitis A virus cellular receptor- HAVCR). TIM-1 is a key cell surface protein that binds TIM-4, leading to T cell proliferation and T helper type 2 (Th2) cytokine production. TIM-1 has also been shown to bind and activate macrophages. Two splice variants for human TIM-1 exist; TIM-1a is predominantly expressed in the liver, whilst TIM-1b is expressed in the kidney. Expression of TIM-1 in the kidney is thought to be upregulated in damaged tissue, and is thought to assist healing. TIM-1 polymorphisms are associated with asthma.

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Western Blot (WB)

app notes :

Western Blot: This item detects a band of approximately 49kDa in human uterus tissue lysate. Western Blotting: Minimum Dilution: 1.0; Maximum Dilution: 2.0ug/ml

other info1 :

Perservative Stabilisers: 0.02% Sodium Azide

other info2 :

Immunogen: 16 amino acid peptide sequence near the centre of human TIM-1. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to human TIM-1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography. Target Species: Human

products description :

MBS221475 detects T cell immunoglobulin mucin-1 (TIM-1), which was first identified as the receptor used by hepatitis A for viral entry (it is also known as the hepatitis A virus cellular receptor- HAVCR). TIM-1 is a key cell surface protein that binds TIM-4, leading to T cell proliferation and T helper type 2 (Th2) cytokine production. TIM-1 has also been shown to bind and activate macrophages. Two splice variants for human TIM-1 exist; TIM-1a is predominantly expressed in the liver, whilst TIM-1b is expressed in the kidney. Expression of TIM-1 in the kidney is thought to be upregulated in damaged tissue, and is thought to assist healing. TIM-1 polymorphisms are associated with asthma.

ncbi gi num :

153085429

ncbi acc num :

NP_001092884.1

ncbi gb acc num :

NM_001099414.1

uniprot acc num :

Q96D42

ncbi mol weight :

38,720 Da

ncbi summary :

The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

uniprot summary :

TIM-1: May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair. Belongs to the immunoglobulin superfamily. TIM family. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 5q33.2. Cellular Component: integral to membrane. Molecular Function: viral receptor activity. Biological Process: entry of virus into host cell. Disease: Ige Responsiveness, Atopic

size1 :

0.1 mg

price1 :

445 USD

more info or order :

MyBioSource product webpage