RABBIT ANTI HUMAN TOSO (C-TERMINAL) | MyBioSource MBS221472 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI HUMAN TOSO (C-TERMINAL)

catalog :

MBS221472

quantity :

0.1 mg

price :

320 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS221472

products type :

Antibody

products full name :

RABBIT ANTI HUMAN TOSO (C-TERMINAL)

products short name :

TOSO

other names :

fas apoptotic inhibitory molecule 3 isoform b; Fas apoptotic inhibitory molecule 3; fas apoptotic inhibitory molecule 3; Fc mu receptor; IgM Fc receptor; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso; Fas apoptotic inhibitory molecule 3; Regulator of Fas-induced apoptosis Toso

products gene name :

TOSO

other gene names :

FAIM3; FAIM3; FCMR; TOSO; TOSO

uniprot entry name :

FAIM3_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse (Expected from Sequence), Rat (Expected from Sequence)

sequence length :

278

specificity :

This item detects an epitope within the C-terminal (CT) region of human Toso, also known as Fas Apoptotic Inhibitory Molecule 3 (FAIM3). Toso is expressed by lymphoid and haematopoietic cells and is up-regulated by T-cell activation. Toso expressing cells have increased resistance to Fas-, FADD-, and TNFalpha-induced apoptosis. Toso is membrane bound, and is thought to directly bind to FADD, disrupting DISC formation and thus inhibiting caspase-8 activation. Toso is a potential proto-oncogene, and could be a therapeutic target for use in the treatment of autoimmune diseases. Despite its predicted molecular weight, Toso often migrates at 60kDa in SDS PAGE.

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 0.5 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Western Blot (WB)

app notes :

Western Blot: This item detects a band of approximately 43kDa in human lung tissue lysate. Western Blotting: Minimum Dilution: 1; Maximum Dilution: 2ug/ml

other info1 :

Perservative Stabilisers: 0.02% Sodium Azide

other info2 :

Immunogen: A 13 amino acid peptide from near the carboxy terminus of human Toso. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to human Toso were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography. Target Species: Human

products description :

MBS221472 detects an epitope within the C-terminal (CT) region of human Toso, also known as Fas Apoptotic Inhibitory Molecule 3 (FAIM3). Toso is expressed by lymphoid and haematopoietic cells and is up-regulated by T-cell activation. Toso expressing cells have increased resistance to Fas-, FADD-, and TNFalpha-induced apoptosis. Toso is membrane bound, and is thought to directly bind to FADD, disrupting DISC formation and thus inhibiting caspase-8 activation. Toso is a potential proto-oncogene, and could be a therapeutic target for use in the treatment of autoimmune diseases. Despite its predicted molecular weight, Toso often migrates at 60kDa in SDS PAGE.

ncbi gi num :

216547554

ncbi acc num :

NP_001135945.1

ncbi gb acc num :

NM_001142473.1

uniprot acc num :

O60667

ncbi mol weight :

33,828 Da

ncbi summary :

Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]

uniprot summary :

FAIM3: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Apoptosis. Chromosomal Location of Human Ortholog: 1q32.1. Cellular Component: extracellular region; integral to membrane. Biological Process: immune system process; cellular defense response; negative regulation of apoptosis

size1 :

0.1 mg

price1 :

320 USD

more info or order :

MyBioSource product webpage