RABBIT ANTI HUMAN PACE4 | MyBioSource MBS221402 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI HUMAN PACE4

catalog :

MBS221402

quantity :

0.05 mg

price :

705 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS221402

products type :

Antibody

products full name :

RABBIT ANTI HUMAN PACE4

products short name :

PACE4

other names :

proprotein convertase subtilisin/kexin type 6 isoform i preproprotein; Proprotein convertase subtilisin/kexin type 6; proprotein convertase subtilisin/kexin type 6; paired basic amino acid cleaving enzyme 4; paired basic amino acid cleaving system 4; subtilisin-like proprotein convertase 4; subtilisin/kexin-like protease PACE4; proprotein convertase subtilisin/kexin type 6; Paired basic amino acid cleaving enzyme 4; Subtilisin-like proprotein convertase 4; SPC4; Subtilisin/kexin-like protease PACE4

products gene name :

PACE4

other gene names :

PCSK6; PCSK6; SPC4; PACE4; PACE4; SPC4

uniprot entry name :

PCSK6_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

sequence length :

895

specificity :

This item detects an epitope within the internal region of human Paired basic amino acid cleaving system 4 (PACE4). PACE4 belongs to the subtilisin-like proprotein convertase family, and is a 100kD calcium dependent serine endoprotease located in the endoplasmic reticulum. It cleaves its substrates at their paired basic amino acid processing sites, converting them into their biologically active products. Several PACE4 substrates have been identified, including transforming growth factor beta-related proteins, proalbumin and von Willebrand factor. In mouse, PACE4 has been shown to increase tumor cell invasiveness, and thus enhance tumor progression. It is thought to have a similar role in humans.

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Paraffin

app notes :

Immunohistology - Paraffin: Minimum Dilution: 15; Maximum Dilution: 25ug/ml

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3)

other info2 :

Immunogen: Synthetic peptide: internal domain of human PACE4. Histology Positive Control Tissue: Brain, cortex. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to PACE4 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography. Target Species: Human

products description :

MBS221402 detects an epitope within the internal region of human Paired basic amino acid cleaving system 4 (PACE4). PACE4 belongs to the subtilisin-like proprotein convertase family, and is a 100kD calcium dependent serine endoprotease located in the endoplasmic reticulum. It cleaves its substrates at their paired basic amino acid processing sites, converting them into their biologically active products. Several PACE4 substrates have been identified, including transforming growth factor beta-related proteins, proalbumin and von Willebrand factor. In mouse, PACE4 has been shown to increase tumor cell invasiveness, and thus enhance tumor progression. It is thought to have a similar role in humans.

ncbi gi num :

604723363

ncbi acc num :

NP_001278238.1

ncbi gb acc num :

NM_001291309.1

uniprot acc num :

P29122

ncbi mol weight :

105,375 Da

ncbi pathways :

Developmental Biology Pathway 477129!!NGF Processing Pathway 106440!!Signal Transduction Pathway 477114!!Signaling By NODAL Pathway 477130!!Signalling By NGF Pathway 106439

ncbi summary :

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]

size :

0.05 mg

price :

705 USD