SHEEP ANTI HUMAN HAPTOGLOBIN | MyBioSource MBS221308 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

SHEEP ANTI HUMAN HAPTOGLOBIN

catalog :

MBS221308

quantity :

1 mL

price :

280 USD

clonality :

polyclonal

host :

sheep

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS221308

products type :

Antibody

products full name :

SHEEP ANTI HUMAN HAPTOGLOBIN

products short name :

HAPTOGLOBIN

other names :

haptoglobin isoform 2 preproprotein; Haptoglobin; haptoglobin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide; zonulin; haptoglobin; ZonulinCleaved into the following 2 chains:Haptoglobin alpha chain; Haptoglobin beta chain

other gene names :

HP; HP; BP; HPA1S; HP2ALPHA2

uniprot entry name :

HPT_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Sheep

reactivity :

Cat, Dog, Horse, Mouse, Pig, Rabbit, Rat

sequence length :

347

specificity :

This item recognises haptoglobulin, a plasma protein that has high affinity for haemoglobin.

form :

Purified. Purified IgG - liquid

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunodiffusion (ID)

app notes :

Immunodiffusion: Maximum Dilution: Neat

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide. 0.1% EACA. 0.01% Benzamidine. 1mM EDTA

other info2 :

Immunogen: Human haptoglobulin purified from serum. Buffer Solution: Glycine buffered saline. Antiserum Preparation: Antisera to human haptoglobulin were raised by repeated immunisation of sheep with highly purified antigen. Purified IgG was prepared by ion exchange chromatography. Target Species: Human

products description :

MBS221308 recognises haptoglobulin, a plasma protein that has high affinity for haemoglobin.

ncbi gi num :

186910296

ncbi acc num :

NP_001119574.1

ncbi gb acc num :

NM_001126102.1

uniprot acc num :

P00738

ncbi mol weight :

38,452 Da

ncbi pathways :

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Scavenging Of Heme From Plasma Pathway (771600); Amb2 Integrin Signaling Pathway (137945)

ncbi summary :

This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

uniprot summary :

HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 16q22.2. Cellular Component: extracellular space; extracellular region. Molecular Function: antioxidant activity; protein binding; hemoglobin binding; catalytic activity. Biological Process: receptor-mediated endocytosis; response to hydrogen peroxide; metabolic process; immune system process; negative regulation of oxidoreductase activity; defense response to bacterium; acute-phase response; defense response. Disease: Anhaptoglobinemia

size1 :

1 mL

price1 :

280 USD

more info or order :

MyBioSource product webpage