RABBIT ANTI HUMAN VITAMIN D BINDING PROTEIN | MyBioSource MBS221218 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI HUMAN VITAMIN D BINDING PROTEIN

catalog :

MBS221218

quantity :

1 mL

price :

390 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS221218

products type :

Antibody

products full name :

RABBIT ANTI HUMAN VITAMIN D BINDING PROTEIN

products short name :

VITAMIN D BINDING PROTEIN

other names :

vitamin D-binding protein isoform 1; Vitamin D-binding protein; vitamin D-binding protein; VDB; epididymis secretory protein Li 51; gc-globulin; vitamin D-binding alpha-globulin; group-specific component (vitamin D binding protein); Gc-globulin; Group-specific component

other gene names :

GC; GC; DBP; GRD3; VDBG; VDBP; DBP/GC; HEL-S-51; DBP; VDB

uniprot entry name :

VTDB_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

sequence length :

493

specificity :

This item recognizes Vitamin D binding protein (VDBP), the major carrier protein of vitamin D that also transports components such as fatty acids and endotoxins and has an important role in the actin scaveging system. VDBP is a 52-58 kDa plasma protein synthesized mainly by hepatocytes. Polymorphisms in the gene give rise to three major electrophoretic variants, Gc1, Gc1s and Gc1f that differ by amino acid substitutions as well as glycosylations. The physiological significance of these phenotypes has yet to be determined.

form :

Purified. Purified Ig - liquid

concentration :

Approximate Protein Concentration: 5.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

ELISA (EIA)

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified Ig prepared by affinity chromatography on Protein G

other info2 :

Immunogen: Native human vitamin D binding protein. Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

MBS221218 recognizes Vitamin D binding protein (VDBP), the major carrier protein of vitamin D that also transports components such as fatty acids and endotoxins and has an important role in the actin scaveging system. VDBP is a 52-58 kDa plasma protein synthesized mainly by hepatocytes. Polymorphisms in the gene give rise to three major electrophoretic variants, Gc1, Gc1s and Gc1f that differ by amino acid substitutions as well as glycosylations. The physiological significance of these phenotypes has yet to be determined.

ncbi gi num :

32483410

ncbi acc num :

NP_000574.2

ncbi gb acc num :

NM_000583.3

uniprot acc num :

P02774

ncbi mol weight :

55,123 Da

ncbi pathways :

Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Metabolism Of Steroid Hormones And Vitamin D Pathway (106150); Vitamin D (calciferol) Metabolism Pathway (160956); Vitamin D Synthesis Pathway (198764)

ncbi summary :

The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

uniprot summary :

GC: Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. Belongs to the ALB/AFP/VDB family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 4q12-q13. Cellular Component: lysosomal lumen; extracellular space; extracellular region; cytosol. Molecular Function: vitamin D binding; actin binding; vitamin transporter activity. Biological Process: steroid metabolic process; vitamin transport; vitamin D metabolic process. Disease: Graves Disease, Susceptibility To, 1

size1 :

1 mL

price1 :

390 USD

more info or order :

MyBioSource product webpage