antibody

RABBIT ANTI HUMAN SUBSTANCE P

MBS221158

0.5 mL

340 USD

polyclonal

rabbit

nonconjugated

human, mouse, chicken

Antibody

RABBIT ANTI HUMAN SUBSTANCE P

SUBSTANCE P

protachykinin-1 isoform beta; Protachykinin-1; protachykinin-1; PPT; neurokinin 1; neurokinin 2; neurokinin A; neurokinin alpha; neuromedin L; neuropeptide K; neuropeptide gamma; preprotachykinin; substance K; substance P; tachykinin 2; tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma); tachykinin, precursor 1; PPTCleaved into the following 5 chains:Substance P; Neurokinin A; NKAAlternative name(s):Neuromedin L; Substance K

TAC1; TAC1; NK2; NPK; NKNA; TAC2; Hs.2563; NKA; NKNA; TAC2; NKA; NPK

TKN1_HUMAN

Polyclonal

IgG

Rabbit

Chicken, Mouse

129

Purified. Purified IgG - liquid

Approximate Protein Concentration: 5.0 mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Shelf Life: 18 months from date of despatch.

Immunohistology Frozen, Immunofluorescence (IF), Immunohistology Paraffin*

Immunohistology - Frozen: Minimum Dilution: 1/50; Maximum Dilution: 1/200;. Immunohistology - Paraffin: Minimum Dilution: 1/50; Maximum Dilution: 1/200; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein G

Histology Positive Control Tissue: Appendix. Buffer Solution: Phosphate buffered saline. Target Species: Human

Rabbit anti Human Substance P antibody recognizes human Protachykinin-1, also known as PPT. Protachykinin-1 is a 129 amino acid ~15kDa tachychinin involved in the excitation of neurons. Protachykinin-1 can be cleaved into a number of chains including substance P, neurokinin A, neuropeptide K, neuropeptide gamma and c-terminal flankning peptide. Rabbit anti Human Substance P antibody recognizes an epitope withing the substance P region of the molecule. There are potentially four isoforms of Protachykinin-1 (alpha - delta ) formed by alternative splicing, all containing the substance P peptide region (UniProt: P20366). Rabbit anti Human Substance P antibody stains substance P secreting cells of the external median eminance of the hypothalamus and specific cells of the GI tract. Rabbit anti Human Substance P antibody also stains neuronal structures.

4507341

NP_003173.1

NM_003182.2

P20366

11,376 Da

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Metabolic Disorders Of Biological Oxidation Enzymes Pathway (1127637); Peptide Ligand-binding Receptors Pathway (106358); SIDS Susceptibility Pathways (198901)

This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

TAC1: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Belongs to the tachykinin family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 7q21-q22. Cellular Component: extracellular space; cell soma; axon; extracellular region; plasma membrane. Molecular Function: protein binding; substance P receptor binding. Biological Process: positive regulation of synaptic transmission, cholinergic; tachykinin signaling pathway; negative regulation of heart rate; insemination; positive regulation of synaptic transmission, GABAergic; response to hormone stimulus; response to morphine; response to pain; response to lipopolysaccharide; sensory perception of pain; positive regulation of saliva secretion; positive regulation of ossification; synaptic transmission; elevation of cytosolic calcium ion concentration; long-term memory; cell-cell signaling; positive regulation of acute inflammatory response; positive regulation of lymphocyte proliferation; neuropeptide signaling pathway; regulation of blood pressure; positive regulation of stress fiber formation; positive regulation of action potential; inflammatory response; detection of abiotic stimulus; associative learning

0.5 mL

340 USD