SHEEP ANTI HUMAN 14-3-3 PROTEIN | MyBioSource MBS221102 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

SHEEP ANTI HUMAN 14-3-3 PROTEIN

catalog :

MBS221102

quantity :

1 mL

price :

375 USD

clonality :

polyclonal

host :

sheep

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS221102

products type :

Antibody

products full name :

SHEEP ANTI HUMAN 14-3-3 PROTEIN

products short name :

14-3-3

other names :

14-3-3 protein theta; 14-3-3 protein theta; 14-3-3 protein theta; 14-3-3 protein T-cell; 14-3-3 protein tau; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta; 14-3-3 protein T-cell; 14-3-3 protein tau; Protein HS1

products gene name :

14-3-3 PROTEIN

other gene names :

YWHAQ; YWHAQ; 1C5; HS1; 14-3-3

uniprot entry name :

1433T_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Sheep

sequence length :

245

specificity :

This item recognises the lower molecular weight subunit (26 kD) of protein 14-3-3.The 14-3-3 family consists of 30kD proteins that are involved in multiple cellular processes including protein kinase signalling pathways, regulation of cell cycle progression, transcription and intracellular trafficking. Protein interactions with 14-3-3 show distinct preferences for its different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein.

form :

Purified. Purified Ig - liquid

concentration :

Ig concentration 2.5 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Western Blot (WB)

app notes :

Western Blotting: Minimum Dilution: 1/10; Maximum Dilution: 1/50

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified Ig prepared by affinity chromatography on Protein G

other info2 :

Immunogen: Native, purified from pathogen-free normal human brain. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to 14-3-3 were raised by repeated immunisations of sheep with highly purified antigen. Target Species: Human

products description :

MBS221102 recognises the lower molecular weight subunit (26 kD) of protein 14-3-3. The 14-3-3 family consists of 30kD proteins that are involved in multiple cellular processes including protein kinase signalling pathways, regulation of cell cycle progression, transcription and intracellular trafficking. Protein interactions with 14-3-3 show distinct preferences for its different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein.

ncbi gi num :

5803227

ncbi acc num :

NP_006817.1

ncbi gb acc num :

NM_006826.3

ncbi mol weight :

27,764 Da

ncbi pathways :

Activation Of BAD And Translocation To Mitochondria Pathway (105659); Activation Of BH3-only Proteins Pathway (105658); Alpha6-Beta4 Integrin Signaling Pathway (198807); Apoptosis Pathway (105648); Calcium Regulation In The Cardiac Cell Pathway (198906); Cell Cycle Pathway (198811); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); Class I PI3K Signaling Events Mediated By Akt Pathway (138020); Epstein-Barr Virus Infection Pathway (585562)

ncbi summary :

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]

uniprot summary :

14-3-3 theta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Associates with c-BCR and BCR-Abl. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 2p25.1. Cellular Component: focal adhesion; cytoplasmic vesicle membrane; membrane; cytoplasm; cytosol. Molecular Function: protein domain specific binding; protein binding; protein N-terminus binding. Biological Process: substantia nigra development; apoptosis; small GTPase mediated signal transduction; negative regulation of transcription, DNA-dependent; protein targeting

size1 :

1 mL

price1 :

375 USD

more info or order :

MyBioSource product webpage