SHEEP ANTI HUMAN PROLACTIN RECEPTOR | MyBioSource MBS221098 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

SHEEP ANTI HUMAN PROLACTIN RECEPTOR

catalog :

MBS221098

quantity :

1 mL

price :

280 USD

clonality :

polyclonal

host :

sheep

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS221098

products type :

Antibody

products full name :

SHEEP ANTI HUMAN PROLACTIN RECEPTOR

products short name :

PROLACTIN RECEPTOR

other names :

prolactin receptor isoform 1; Prolactin receptor; prolactin receptor; hPRL receptor; secreted prolactin binding protein; prolactin receptor

other gene names :

PRLR; PRLR; HPRL; MFAB; hPRLrI; PRL-R

uniprot entry name :

PRLR_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Sheep

reactivity :

Mouse (Expected from Sequence), Rat (Expected from Sequence)

sequence length :

622

specificity :

This item recognises Prolactin receptor, a widely-expressed transmembrane protein that binds prolactin with high affinity. The N terminal sequence used to raise this antibody exhibits a high degree of homology with rat and mouse prolactin receptors.

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 5.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

ELISA (EIA), Western Blot (WB)

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein G.

other info2 :

Immunogen: Synthetic peptide corresponding to the amino acids 1 - 14 of the native molecule conjugated to Keyhole limpet Haemocyanin. Peptide sequence: QLPPGKPEIFKCRS. Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

MBS221098 recognises Prolactin receptor, a widely-expressed transmembrane protein that binds prolactin with high affinity. The N terminal sequence used to raise this antibodyexhibits a high degree of homology with rat and mouseprolactin receptors.

ncbi gi num :

4506107

ncbi acc num :

NP_000940.1

ncbi gb acc num :

NM_000949.6

uniprot acc num :

P16471

ncbi mol weight :

35,011 Da

ncbi pathways :

Adipogenesis Pathway (198832); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); ErbB4 Signaling Events Pathway (137991); Growth Hormone Receptor Signaling Pathway (477128); Immune System Pathway (106386); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); Neuroactive Ligand-receptor Interaction Pathway (83053)

ncbi summary :

This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]

uniprot summary :

PRLR: receptor for the anterior pituitary hormone prolactin and placental lactogen I and II. Interacts with Cyclophilin A, differentially regulating various signaling pathways from the PrlR. Prolactin signaling is attenuated by threonine and tyrosine phosphorylation. Two alternative splice isoforms have been identified. Protein type: Membrane protein, integral; Receptor, cytokine. Chromosomal Location of Human Ortholog: 5p13.2. Cellular Component: cell surface; integral to membrane; extracellular region; plasma membrane. Molecular Function: protein binding; protein homodimerization activity; peptide hormone binding; ornithine decarboxylase activator activity; metal ion binding; prolactin receptor activity. Biological Process: lactation; regulation of cell adhesion; transmembrane receptor protein tyrosine kinase activation (dimerization); cell surface receptor linked signal transduction; T cell activation; regulation of epithelial cell differentiation; tyrosine phosphorylation of JAK2 protein; steroid biosynthetic process; embryo implantation; negative regulation of apoptosis. Disease: Multiple Fibroadenomas Of The Breast; Hyperprolactinemia

size1 :

1 mL

price1 :

280 USD

more info or order :

MyBioSource product webpage