RABBIT ANTI HUMAN NON-NEURONAL ENOLASE | MyBioSource MBS221031 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI HUMAN NON-NEURONAL ENOLASE

catalog :

MBS221031

quantity :

1 mL

price :

365 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS221031

products type :

Antibody

products full name :

RABBIT ANTI HUMAN NON-NEURONAL ENOLASE

products short name :

NON-NEURONAL ENOLASE

other names :

c-myc promoter-binding protein-1 isoform MBP-1; Alpha-enolase; alpha-enolase; c-myc promoter-binding protein-1; 2-phospho-D-glycerate hydro-lyase; MYC promoter-binding protein 1; alpha enolase like 1; enolase-alpha; non-neural enolase; phosphopyruvate hydratase; plasminogen-binding protein; tau-crystallin; enolase 1, (alpha); 2-phospho-D-glycerate hydro-lyase; C-myc promoter-binding protein; Enolase 1; MBP-1; MPB-1; Non-neural enolase; NNE; Phosphopyruvate hydratase; Plasminogen-binding protein

other gene names :

ENO1; ENO1; NNE; PPH; MPB1; ENO1L1; ENO1L1; MBPB1; MPB1; NNE

uniprot entry name :

ENOA_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

sequence length :

341

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 5mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen, ELISA (EIA), Immunohistology Paraffin, Western Blot (WB)

app notes :

Immunohistology - Frozen: Minimum Dilution: 1/25; Maximum Dilution: 1/100;. Immunohistology - Paraffin: Minimum Dilution: 1/25; Maximum Dilution: 1/100

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3). Preparation: Purified IgG prepared by affinity chromatography on Protein G

other info2 :

Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

Rabbit anti Human non-neuronal enolase polyclonal antibody recognises human non-neuronal enolase, also known as alpha enolase or enolase 1. Rabbit anti non-neuronal enolase demostrates less than 0.1% cross-reactivity with neuron-specific enolase. Non-neuronal enolase is a glycolytic enzyme composed of homodimeric alpha enolase subunits and is expressed in most human tissues. The gene coding for the 48kDa form of non-neuronal enolase also codes for a shorter 37kDa isoform, myc-binding protein 1 (MBP-1) lacking the N-terminal 93 amino acids of non-neuronal enolase.

ncbi gi num :

319996655

ncbi acc num :

NP_001188412.1

ncbi gb acc num :

NM_001201483.1

uniprot acc num :

P06733

ncbi mol weight :

36,928 Da

ncbi pathways :

Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); Disease Pathway (530764); Gluconeogenesis Pathway (106204); Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway (413342); Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway (468196); Glucose Metabolism Pathway (106199); Glycogen Storage Diseases Pathway (1127581)

ncbi summary :

This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]

uniprot summary :

ENO1: an abundant cytoplasmic enzyme with 2-phospho-D-glycerate hydro-lyase activity. A target of excess protein nitration in Alzheimer disease (AD) brain. Tau-crystallin, a structural lens protein, is produced from an alternative translation start in the enolase gene. Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.2.1.11; Transcription, coactivator/corepressor; Lyase. Chromosomal Location of Human Ortholog: 1p36.2. Cellular Component: extracellular space; phosphopyruvate hydratase complex; membrane; cytoplasm; plasma membrane; M band; cytosol; nucleus. Molecular Function: protein binding; DNA binding; magnesium ion binding; phosphopyruvate hydratase activity; transcription factor activity; transcription corepressor activity. Biological Process: glycolysis; transcription, DNA-dependent; response to virus; carbohydrate metabolic process; glucose metabolic process; pathogenesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; gluconeogenesis

size1 :

1 mL

price1 :

365 USD

more info or order :

MyBioSource product webpage