catalog number :
MBS221001
products full name :
SHEEP ANTI HUMAN ALPHA 1 MICROGLOBULIN
products short name :
ALPHA 1 MICROGLOBULIN
other names :
protein AMBP preproprotein; Protein AMBP; protein AMBP; bikunin; complex-forming glycoprotein heterogeneous in charge; growth-inhibiting protein 19; inter-alpha-trypsin inhibitor light chain; protein HC; trypstatin; uristatin; uronic-acid-rich protein; alpha-1-microglobulin/bikunin precursor; Alpha-1 microglycoprotein; Complex-forming glycoprotein heterogeneous in charge
other gene names :
AMBP; AMBP; A1M; HCP; ITI; UTI; EDC1; HI30; ITIL; IATIL; ITILC; HCP; ITIL; Protein HC; ITI-LC
uniprot entry name :
AMBP_HUMAN
form :
Purified. Purified IgG - liquid
concentration :
Approximate Protein Concentration: 5mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Shelf Life: 18 months from date of despatch.
tested application :
ELISA (EIA), Immunodiffusion (ID)
app notes :
ELISA: Minimum Dilution: 1/500; Maximum Dilution: 1/1000
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide (NaN3)> . Preparation: Purified IgG prepared by affinity chromatography on Protein G
other info2 :
Immunogen: Highly pure human alpha-1-microglobulin, prepared from the urine of patients with chronic renal proteinuria (molecular weight 25-30 kD). Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to human alpha-1-microglubulin were raised by repeated immunisations of sheep with highly purified antigen. Target Species: Human
products description :
Sheep anti Human alpha 1 microglobulin antibody recognizes human alpha 1 microglobulin. Sheep anti Human alpha 1 microglobulin antibody does not demonstrate any cross reactivity with urine albumin, retinol binding protein or beta-2 microglobulin in performed testing.
ncbi acc num :
NP_001624.1
ncbi gb acc num :
NM_001633.3
ncbi mol weight :
38,999 Da
ncbi pathways :
Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Scavenging Of Heme From Plasma Pathway (771600)
ncbi summary :
This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]
uniprot summary :
AMBP: Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 9q32-q33. Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; plasma membrane; extracellular region. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; protein homodimerization activity; calcium oxalate binding; heme binding; IgA binding; calcium channel inhibitor activity. Biological Process: receptor-mediated endocytosis; negative regulation of JNK cascade; viral reproduction; heme catabolic process; negative regulation of immune response; protein catabolic process; female pregnancy; cell adhesion; protein-chromophore linkage