catalog number :
MBS220991
products full name :
SHEEP ANTI HUMAN MMP-13
products short name :
MMP-13
other names :
collagenase 3 preproprotein; Collagenase 3; collagenase 3; matrix metallopeptidase 13 (collagenase 3); matrix metalloproteinase 13 (collagenase 3); matrix metallopeptidase 13; Matrix metalloproteinase-13; MMP-13
products gene name :
MMP-13
other gene names :
MMP13; MMP13; CLG3; MANDP1; MMP-13; MMP-13
uniprot entry name :
MMP13_HUMAN
reactivity :
Mouse, Rat (Expected from Sequence)
specificity :
This item is specific for matrix metalloproteinase-13. It does not react with MMPs 1, 2, 3 or 9 or fibronectin in Western blotting.
form :
Purified. Ig fraction - liquid
storage stability :
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Immunohistology Paraffin*, Western Blot (WB)
app notes :
Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. . Western Blotting: Maximum Dilution: 1/1000
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide (NaN3). 0.1% EACA. 0.01% Benzamidine. 1mM EDTA
other info2 :
Immunogen: Synthetic peptide corresponding to 26 amino acids from the human MMP-13 sequence. Buffer Solution: Glycine buffered saline. Target Species: Human
products description :
MBS220991 is specific for matrix metalloproteinase-13. It does not react with MMPs 1, 2, 3 or 9 or fibronectin in Western blotting.
ncbi acc num :
NP_002418.1
ncbi gb acc num :
NM_002427.3
ncbi mol weight :
53,820 Da
ncbi pathways :
AGE/RAGE Pathway 698754!!Activation Of Matrix Metalloproteinases Pathway 576264!!Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway 730306!!Collagen Degradation Pathway 730309!!Collagen Formation Pathway 645288!!Degradation Of The Extracellular Matrix Pathway 576263!!Endochondral Ossification Pathway 198812!!Extracellular Matrix Organization Pathway 576262!!Matrix Metalloproteinases Pathway 198900!!Oncostatin M Signaling Pathway 711361
ncbi summary :
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]