SHEEP ANTI HUMAN GLUTAMATE RECEPTOR 5 | MyBioSource MBS220880 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

SHEEP ANTI HUMAN GLUTAMATE RECEPTOR 5

catalog :

MBS220880

quantity :

1 mL

price :

490 USD

clonality :

polyclonal

host :

sheep

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, Rhesus monkey

application :

western blot, ELISA, enzyme immunoassay

product information

catalog number :

MBS220880

products type :

Antibody

products full name :

SHEEP ANTI HUMAN GLUTAMATE RECEPTOR 5

products short name :

GluR5

other names :

glutamate receptor ionotropic, kainate 1 isoform 1; Glutamate receptor ionotropic, kainate 1; glutamate receptor ionotropic, kainate 1; excitatory amino acid receptor 3; gluR-5; glutamate receptor 5; glutamate receptor, ionotropic, kainate 1; Excitatory amino acid receptor 3; EAA3; Glutamate receptor 5; GluR-5; GluR5

other gene names :

GRIK1; GRIK1; EAA3; EEA3; GLR5; GLUR5; GluK1; GLUR5; GluK1; EAA3; GluR-5; GluR5

uniprot entry name :

GRIK1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Sheep

reactivity :

Dog (Expected from Sequence), Mouse (Expected from Sequence), Rabbit (Expected from Sequence), Rat (Expected from Sequence), Rhesus Monkey (Expected from Sequence)

sequence length :

918

specificity :

This item recognizes the human glutamate receptor 5 (GluR5), an ionotropic receptor that mediates excitatory neurotransmission.

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 5.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

Western Blot: This item detects a band at approximately 125kDa in human brain lysate under reducing conditions. Western Blotting: Minimum Dilution: 1/100; Maximum Dilution: 1/500

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3). Preparation: Purified Ig prepared by affinity chromatography on Protein G

other info2 :

Immunogen: Synthetic peptide, TCHQRRTQRKETVA, conjugated to Keyhole Limpet Hemocyanin (KLH). Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

MBS220880 recognizes the human glutamate receptor 5 (GluR5), an ionotropic receptor that mediates excitatory neurotransmission.

ncbi gi num :

4504117

ncbi acc num :

NP_000821.1

ncbi gb acc num :

NM_000830.3

uniprot acc num :

P39086

ncbi mol weight :

102,631 Da

ncbi pathways :

Activation Of Ca-permeable Kainate Receptor Pathway (161046); Activation Of Kainate Receptors Upon Glutamate Binding Pathway (161043); Activation Of Na-permeable Kainate Receptors Pathway (161045); Glutamatergic Synapse Pathway (213818); Glutamatergic Synapse Pathway (213811); Ionotropic Activity Of Kainate Receptors Pathway (161044); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Neuronal System Pathway (106513); Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway (106534)

ncbi summary :

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG- Q- R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

GluR5: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 21q22.11. Cellular Component: presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; integral to plasma membrane; dendrite; plasma membrane; cell junction. Molecular Function: kainate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity. Biological Process: synaptic transmission, glutamatergic; nervous system development; central nervous system development; regulation of synaptic transmission, glutamatergic; glutamate signaling pathway; positive regulation of synaptic transmission, GABAergic; negative regulation of synaptic transmission, glutamatergic; synaptic transmission; regulation of inhibitory postsynaptic membrane potential; behavioral response to pain; ionotropic glutamate receptor signaling pathway; transport; adult behavior; regulation of excitatory postsynaptic membrane potential; positive regulation of gamma-aminobutyric acid secretion

size1 :

1 mL

price1 :

490 USD