antibody

RABBIT ANTI MOUSE COLLAGEN I

MBS220762

0.1 mL

500 USD

polyclonal

rabbit

nonconjugated

ELISA, immunocytochemistry, radioimmunoassay, enzyme immunoassay

Antibody

RABBIT ANTI MOUSE COLLAGEN I

COLLAGEN I

collagen alpha-2(I) chain; Collagen alpha-2(I) chain; collagen alpha-2(I) chain; collagen alpha-2(I) chain; alpha-2 type I collagen; collagen COL1A2; osteogenesis imperfecta; procollagen, type I, alpha 2; collagen, type I, alpha 2; Alpha-2 type I collagen

Col1a2; Col1a2; oim; Cola2; Cola-2; Col1a-2; AA960264; AI325291; Cola2

CO1A2_MOUSE

Polyclonal

IgG

Rabbit

1372

This item is specific for mouse collagen type I.Less than 1% cross reactivity has been observed with mouse collagen, types II, VI and III and human, chicken and rat collagen, type I.

Purified. Purified Ig - liquid

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

Immunohistology Frozen, ELISA (EIA), Immunofluorescence (IF), Immunohistology Paraffin, Radioimmunoassays (RIA)

ELISA: Minimum Dilution: 1/100; Maximum Dilution: 1/400;. Immunofluorescence: Minimum Dilution: 1/50; Maximum Dilution: 1/100;. Immunohistology - Paraffin: Minimum Dilution: 1/250; Maximum Dilution: 1/1000

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified Ig prepared by affinity chromatography

Immunogen: Native type I collagen from mouse skin. Buffer Solution: Phosphate buffered saline. Target Species: Mouse

MBS220762 is specific for mouse collagen type I.Less than 1% cross reactivity has been observed with mouse collagen, types II, VI and III and human, chicken and rat collagen, type I.

111120329

NP_031769.2

NM_007743.2

129,557 Da

Amoebiasis Pathway (167330); Amoebiasis Pathway (167191); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (1110305); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (1110598); Collagen Biosynthesis And Modifying Enzymes Pathway (1110304); Collagen Formation Pathway (1110303); ECM-receptor Interaction Pathway (83265); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (1110302); Focal Adhesion Pathway (198353)

COL1A2: Type I collagen is a member of group I collagen (fibrillar forming collagen). Defects in COL1A2 are the cause of Ehlers-Danlos syndrome type 7B (EDS7B). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7B is marked by bilateral congenital hip dislocation, hyperlaxity of the joints, and recurrent partial dislocations. Defects in COL1A2 are a cause of osteogenesis imperfecta type 1 (OI1). A dominantly inherited connective tissue disorder characterized by bone fragility and blue sclerae. Osteogenesis imperfecta type 1 is non-deforming with normal height or mild short stature, and no dentinogenesis imperfecta. Defects in COL1A2 are a cause of osteogenesis imperfecta type 2 (OI2); also known as osteogenesis imperfecta congenita (OIC) or lethal perinatal. A connective tissue disorder characterized by bone fragility, with many perinatal fractures, severe bowing of long bones, undermineralization, and death in the perinatal period due to respiratory insufficiency. Defects in COL1A2 are the cause of Ehlers-Danlos syndrome autosomal recessive cardiac valvular form (EDSCV). A connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. In addition to joint laxity, skin hyperextensibility and friability, and abnormal scar formation, patients have mitral valve prolapse and insufficiency, mitral regurgitation, and aortic insufficiency. Defects in COL1A2 are a cause of osteogenesis imperfecta type 3 (OI3). A connective tissue disorder characterized by progressively deforming bones, very short stature, a triangular face, severe scoliosis, grayish sclera, and dentinogenesis imperfecta. Defects in COL1A2 are a cause of osteogenesis imperfecta type 4 (OI4); also known as osteogenesis imperfecta with normal sclerae. A connective tissue disorder characterized by moderately short stature, mild to moderate scoliosis, grayish or white sclera and dentinogenesis imperfecta. A chromosomal aberration involving COL1A2 may be a cause of lipoblastomas, which are benign tumors resulting from transformation of adipocytes, usually diagnosed in children. Translocation t(7;8)(p22;q13) with PLAG1. Belongs to the fibrillar collagen family. Protein type: Secreted, signal peptide; Secreted. Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; collagen; extracellular region; collagen type I; intracellular. Molecular Function: protein binding, bridging; identical protein binding; protein binding; platelet-derived growth factor binding; extracellular matrix structural constituent; metal ion binding; SMAD binding. Biological Process: blood vessel development; collagen fibril organization; skin morphogenesis; transforming growth factor beta receptor signaling pathway; regulation of blood pressure; skeletal development; Rho protein signal transduction

0.1 mL

500 USD