RABBIT ANTI HUMAN BRCA2 | MyBioSource MBS220637 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI HUMAN BRCA2

catalog :

MBS220637

quantity :

1 mL

price :

475 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, chimpanzee, Rhesus monkey

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS220637

products type :

Antibody

products full name :

RABBIT ANTI HUMAN BRCA2

products short name :

BRCA2

other names :

breast cancer type 2 susceptibility protein; Breast cancer type 2 susceptibility protein; breast cancer type 2 susceptibility protein; BRCA1/BRCA2-containing complex, subunit 2; Fanconi anemia group D1 protein; breast and ovarian cancer susceptibility gene, early onset; breast cancer 2 tumor suppressor; breast cancer 2, early onset; Fanconi anemia group D1 protein

products gene name :

BRCA2

other gene names :

BRCA2; BRCA2; FAD; FACD; FAD1; GLM3; BRCC2; FANCD; PNCA2; FANCD1; XRCC11; BROVCA2; FACD; FANCD1

uniprot entry name :

BRCA2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Cat (Expected from Sequence), Chimpanzee (Expected from Sequence), Dog (Expected from Sequence), Horse (Expected from Sequence), Mouse (Expected from Sequence), Rat (Expected from Sequence), Rhesus Monkey (Expected from Sequence)

sequence length :

3418

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 5.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen, Immunohistology Paraffin*

app notes :

Immunohistology - Paraffin: Minimum Dilution: 1/25; Maximum Dilution: 1/100; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein G

other info2 :

Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

Rabbit anti Human BRCA2 antibody recognizes human Breast Cancer Type 2 susceptibility protein (BRCA2), a tumour-suppressor protein reported to be involved in double-strand break repair, homologous recombination and S-phase checkpoint activation.

ncbi gi num :

119395734

ncbi acc num :

NP_000050.2

ncbi gb acc num :

NM_000059.3

uniprot acc num :

P51587

ncbi mol weight :

384,225 Da

ncbi pathways :

Cell Cycle Pathway (530733); DNA Repair Pathway (105837); Double-Strand Break Repair Pathway (105861); FOXM1 Transcription Factor Network Pathway (137935); Fanconi Anemia Pathway (105895); Fanconi Anemia Pathway (377262); Fanconi Anemia Pathway (377128); Homologous DNA Pairing And Strand Exchange Pathway (105870); Homologous Recombination Repair Pathway (105862); Homologous Recombination Pathway (198890)

ncbi summary :

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]

uniprot summary :

BRCA2: involved in double-strand break repair and/or homologous recombination. May participate in S phase checkpoint activation. Interacts with RAD51 and DSS1. Interacts with ubiquitinated FANCD2. Interacts with PALB2, enables the recombinational repair and checkpoint functions. Interacts with WDR16. Defects in BRCA2 are a cause of genetic susceptibility to breast cancer and may underlie susceptibility to uveal melanoma. Protein type: Nuclear receptor co-regulator; DNA repair, damage; Tumor suppressor. Chromosomal Location of Human Ortholog: 13q12.3. Cellular Component: nucleoplasm; centrosome; protein complex; cytoplasm; BRCA2-MAGE-D1 complex; nucleus; secretory granule. Molecular Function: protein binding; gamma-tubulin binding; H4 histone acetyltransferase activity; histone acetyltransferase activity; protease binding; H3 histone acetyltransferase activity; single-stranded DNA binding. Biological Process: positive regulation of transcription, DNA-dependent; cell aging; cytokinesis; positive regulation of mitotic cell cycle; DNA repair; oocyte maturation; regulation of cytokinesis; inner cell mass cell proliferation; negative regulation of mammary gland epithelial cell proliferation; response to UV-C; double-strand break repair via homologous recombination; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; male meiosis I; nucleotide-excision repair; double-strand break repair; response to gamma radiation; hemopoiesis; spermatogenesis; replication fork protection; brain development; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; centrosome duplication; female gonad development; response to X-ray. Disease: Pancreatic Cancer, Susceptibility To, 2; Breast-ovarian Cancer, Familial, Susceptibility To, 2; Breast Cancer; Medulloblastoma; Prostate Cancer; Glioma Susceptibility 3; Tracheoesophageal Fistula With Or Without Esophageal Atresia; Fanconi Anemia, Complementation Group D1; Wilms Tumor 1

size1 :

1 mL

price1 :

475 USD

more info or order :

MyBioSource product webpage