antibody

RABBIT ANTI HUMAN ANDROGEN RECEPTOR

MBS220616

1 mL

455 USD

polyclonal

rabbit

nonconjugated

human, Rhesus monkey

immunohistochemistry, immunohistochemistry - paraffin section

Antibody

RABBIT ANTI HUMAN ANDROGEN RECEPTOR

ANDROGEN RECEPTOR

androgen receptor isoform 1; Androgen receptor; androgen receptor; androgen nuclear receptor variant 2; dihydrotestosterone receptor; nuclear receptor subfamily 3 group C member 4; androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4

AR; AR; KD; AIS; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA; DHTR; NR3C4

ANDR_HUMAN

Polyclonal

IgG

Rabbit

Chimpanzee (Expected from Sequence), Rhesus Monkey (Expected from Sequence)

920

S-T-E-D-T-A-E-Y-S-P-F-K-G-G-Y-T-K

Purified. Purified IgG - liquid

IgG concentration 5.0 mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

Immunohistology Paraffin

Immunohistology: This product does not require protein digestion pre-treatment or antigen retrieval using heat treatment prior to staining of paraffin sections.

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography

Histology Positive Control Tissue: Human Prostate Carcinoma. Buffer Solution: Phosphate buffered saline. Target Species: Human

Rabbit anti Human Androgen Receptor antibody recognizes the human Androgen Receptor (AR) also known as the Dihydrotestosterone receptor or Nuclear receptor subfamily 3 group C member 4. Dihydrotestosterone (DHT) binds with highest affinity to AR and together with testosterone promotes AR transcriptional activity thereby ensuring the development and maintenance of male reproductive functions. AR homodimers recruit a variety of factors including coactivators and mediator proteins whose enzymatic activities promote chromatin remodeling and transcriptional regulation of target genes leading to cell differentiation, survival, and proliferation. Mutated AR is strongly implicated in development of prostate adenocarcinoma and metastases development. AR mutations can also cause spinal bulbar muscular atrophy (Kennedy disease) and partial/ complete androgen insensitivity.

21322252

NP_000035.2

NM_000044.3

P10275

44,643 Da

Alpha6-Beta4 Integrin Signaling Pathway (198807); Androgen Receptor Signaling Pathway (198806); Coregulation Of Androgen Receptor Activity Pathway (138085); FOXA1 Transcription Factor Network Pathway (137979); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); IL-6 Signaling Pathway (198864); Integrated Breast Cancer Pathway (219801); Integrated Pancreatic Cancer Pathway (711360); Nongenotropic Androgen Signaling Pathway (138048)

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

AR: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described. Protein type: Nuclear receptor; Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: Xq12. Cellular Component: nucleoplasm; protein complex; cytoplasm; nuclear chromatin; nucleus. Molecular Function: protein dimerization activity; ligand-dependent nuclear receptor activity; androgen binding; zinc ion binding; beta-catenin binding; transcription factor binding; androgen receptor activity; protein binding; enzyme binding; DNA binding; chromatin binding; transcription factor activity; receptor binding. Biological Process: prostate gland development; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; signal transduction; protein oligomerization; activation of NF-kappaB transcription factor; negative regulation of integrin biosynthetic process; cell proliferation; cell-cell signaling; transport; androgen receptor signaling pathway; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase III promoter; steroid hormone mediated signaling; gene expression; positive regulation of transcription from RNA polymerase II promoter; positive regulation of integrin biosynthetic process; cell growth; sex differentiation; positive regulation of phosphorylation. Disease: Androgen Insensitivity Syndrome; Prostate Cancer; Androgen Insensitivity, Partial; Hypospadias 1, X-linked; Spinal And Bulbar Muscular Atrophy, X-linked 1

1 mL

455 USD