SHEEP ANTI HUMAN ACETYLCHOLINESTERASE | MyBioSource MBS220518 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

SHEEP ANTI HUMAN ACETYLCHOLINESTERASE

catalog :

MBS220518

quantity :

1 mL

price :

340 USD

clonality :

polyclonal

host :

sheep

conjugate :

nonconjugated

reactivity :

human

application :

enzyme immunoassay

product information

catalog number :

MBS220518

products type :

Antibody

products full name :

SHEEP ANTI HUMAN ACETYLCHOLINESTERASE

products short name :

ACETYLCHOLINESTERASE

other names :

acetylcholinesterase isoform E4-E6; Acetylcholinesterase; acetylcholinesterase; Yt blood group; apoptosis-related acetylcholinesterase; acetylcholinesterase (Yt blood group)

other gene names :

ACHE; ACHE; YT; ACEE; ARACHE; N-ACHE; AChE

uniprot entry name :

ACES_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Sheep

sequence length :

614

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 5.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

ELISA (EIA)

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3). Preparation: Purified IgG prepared by affinity chromatography on Protein G

other info2 :

Immunogen: Native from erythrocytes. Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

Sheep anti Human acetylcholinesterase antibody recognizes human acetylcholinesterase. This enzyme terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. It also has a role in neuronal apoptosis. Sheep anti Human Acetylcholinesterase antibody may also react with acetylcholinesterase from other species.

ncbi gi num :

4557239

ncbi acc num :

NP_000656.1

ncbi gb acc num :

NM_000665.4

uniprot acc num :

P22303

ncbi mol weight :

58,352 Da

ncbi pathways :

ATF-2 Transcription Factor Network Pathway (138006); Acetylcholine Synthesis Pathway (198820); Biogenic Amine Synthesis Pathway (198793); Cholinergic Synapse Pathway (217716); Glycerophospholipid Biosynthesis Pathway (645313); Glycerophospholipid Metabolism Pathway (82989); Glycerophospholipid Metabolism Pathway (364); Integrated Pancreatic Cancer Pathway (711360); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976)

ncbi summary :

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]

uniprot summary :

ACHE: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis. Belongs to the type-B carboxylesterase/lipase family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Hydrolase; Lipid Metabolism - glycerophospholipid; EC 3.1.1.7; Membrane protein, GPI anchor. Chromosomal Location of Human Ortholog: 7q22. Cellular Component: Golgi apparatus; extracellular space; cell surface; membrane; perinuclear region of cytoplasm; plasma membrane; extracellular region; basal lamina; synapse; nucleus; neuromuscular junction; cell junction. Molecular Function: collagen binding; protein binding; serine hydrolase activity; protein homodimerization activity; protein self-association; cholinesterase activity; hydrolase activity; beta-amyloid binding; laminin binding; acetylcholinesterase activity; acetylcholine binding. Biological Process: nervous system development; negative regulation of synaptic transmission, cholinergic; muscle development; acetylcholine catabolic process in synaptic cleft; acetylcholine catabolic process; glycerophospholipid biosynthetic process; osteoblast development; cell proliferation; synaptic transmission; synaptogenesis; positive regulation of protein secretion; retina development in camera-type eye; amyloid precursor protein metabolic process; neurotransmitter receptor biosynthetic process; phospholipid metabolic process; receptor internalization; phosphatidylcholine biosynthetic process; response to wounding; regulation of receptor recycling; DNA replication; cell adhesion; protein tetramerization; neurotransmitter biosynthetic process. Disease: Yt Blood Group Antigen

size1 :

1 mL

price1 :

340 USD