antibody

SHEEP ANTI HUMAN INDOLEAMINE 2,3-DIOXYGENASE

MBS220490

0.1 ml

610 USD

polyclonal

sheep

nonconjugated

human, Rhesus monkey

Antibody

SHEEP ANTI HUMAN INDOLEAMINE 2,3-DIOXYGENASE

INDOLEAMINE 2,3-DIOXYGENASE

indoleamine 2,3-dioxygenase 1; Indoleamine 2,3-dioxygenase 1; indoleamine 2,3-dioxygenase 1; indolamine 2,3 dioxygenase; indole 2,3-dioxygenase; indoleamine-pyrrole 2,3-dioxygenase; indoleamine 2,3-dioxygenase 1; Indoleamine-pyrrole 2,3-dioxygenase

IDO1; IDO1; IDO; INDO; IDO-1; IDO; INDO; IDO-1

I23O1_HUMAN

Polyclonal

IgG

Sheep

Marmoset, Rhesus Monkey

403

This item recognises human indoleamine 2,3-dioxygenase (IDO), an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. Reports suggest that IDO is involved in the suppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy.

Ig Fraction. Ig Fraction - liquid

Total protein concentration 27.1 mg/ml

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

Immunohistology Paraffin*, Western Blot (WB)

Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. . Western Blotting: Maximum Dilution: 1/1000

Perservative Stabilisers: 0.09% Sodium Azide

Immunogen: Recombinant human indoleamine 2,3-dioxygenase. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to human indoleamine dioxygenase (IDO) were raised by repeated immunisation of sheep with highly purified antigen. Ig fraction prepared by ammonium sulphate precipitation. Target Species: Human

MBS220490 recognises human indoleamine 2,3-dioxygenase (IDO), an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. Reports suggest that IDO is involved in the suppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy.

4504577

NP_002155.1

NM_002164.5

P14902

45,326 Da

African Trypanosomiasis Pathway 194384!!African Trypanosomiasis Pathway 194323!!L-kynurenine Degradation Pathway 907939!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Amino Acids And Derivatives Pathway 106169!!NAD Biosynthesis II (from Tryptophan) Pathway 138368!!NAD De Novo Biosynthesis Pathway 142215!!Tryptophan Catabolism Pathway 106190!!Tryptophan Metabolism Pathway 82964

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

0.1 ml

610 USD