SHEEP ANTI HUMAN C1q:HRP | MyBioSource MBS220377 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

SHEEP ANTI HUMAN C1q:HRP

catalog :

MBS220377

quantity :

1 mL

price :

380 USD

clonality :

polyclonal

host :

sheep

conjugate :

HRP

reactivity :

human

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS220377

products type :

Antibody

products full name :

SHEEP ANTI HUMAN C1q:HRP

products short name :

C1q

products name syn :

C1QG

other names :

complement C1q subcomponent subunit A; Complement C1q subcomponent subunit A; complement C1q subcomponent subunit A; complement component 1, q subcomponent, alpha polypeptide; complement component C1q, A chain; complement component 1, q subcomponent, A chain

products gene name :

C1q

other gene names :

C1QA; C1QA

uniprot entry name :

C1QA_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Sheep

sequence length :

245

specificity :

Sheep anti human C1q antibody may crossreact with C1q in other species. Sheep anti Human C1q antibody recognizes human C1q, a sub-component of complement C1. C1q associates with complemtn components C1r adn C1s, which are required for the progression of the proteolytic complement cascade. Deficiency of C1q has been associated with lupus erthematosus and glomerulonephritis (Troedson et al. 2013)

form :

HRP. Purified IgG conjugated to Horseradish Peroxidase (HRP) - liquid

concentration :

IgG concentration 1.0mg/ml

storage stability :

Store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

ELISA (EIA)

app notes :

ELISA: Minimum Dilution: 1/100; Maximum Dilution: 1/400

other info1 :

Perservative Stabilisers: 0.01% Thiomersal. HRP Stabiliser. Immunogen: Human C1q

other info2 :

Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to human C1q were raised by repeated immunisation of sheep with highly purified antigen. Purified IgG was prepared from whole serum by protein G affinity chromatography. Target Species: Human

products description :

Sheep anti Human C1q antibody recognizes human C1q, a sub-component of complement C1. C1q associates with complement components C1r and C1s, which are required for the progression of the proteolytic complement cascade. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis (Troedson et al. 2013). Sheep anti human C1q antibody may cross react with C1q in other species.

ncbi gi num :

7705753

ncbi acc num :

NP_057075.1

ncbi gb acc num :

NM_015991.2

ncbi mol weight :

26,017 Da

ncbi pathways :

Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Classical Antibody-mediated Complement Activation Pathway (106409); Complement Activation, Classical Pathway (198823); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); Immune System Pathway (106386)

ncbi summary :

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008]

uniprot summary :

C1QA iso2: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2 )-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1p36.12. Cellular Component: collagen; extracellular region; complement component C1 complex. Molecular Function: protein binding. Biological Process: cell-cell signaling; innate immune response; complement activation, classical pathway; complement activation. Disease: C1q Deficiency

size1 :

1 mL

price1 :

380 USD

more info or order :

MyBioSource product webpage