RABBIT ANTI HUMAN BMP-7:Biotin | MyBioSource MBS220226 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI HUMAN BMP-7:Biotin

catalog :

MBS220226

quantity :

0.05 mg

price :

555 USD

clonality :

polyclonal

host :

rabbit

conjugate :

biotin

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

product information

catalog number :

MBS220226

products type :

Antibody

products full name :

RABBIT ANTI HUMAN BMP-7:Biotin

products short name :

BMP-7

other names :

bone morphogenetic protein 7; Bone morphogenetic protein 7; bone morphogenetic protein 7; osteogenic protein 1; bone morphogenetic protein 7; Osteogenic protein 1; OP-1; INN: Eptotermin alfa

products gene name :

BMP-7

other gene names :

BMP7; BMP7; OP-1; OP1; BMP-7; OP-1

uniprot entry name :

BMP7_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

sequence length :

431

form :

Biotin. Purified IgG conjugated to Biotin - lyophilised

concentration :

IgG concentration 0.1 mg/ml after reconstitution

storage stability :

Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of reconstitution.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

ELISA: Minimum Dilution: 0.25; Maximum Dilution: 1.0ug/ml;. Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml

other info1 :

Reconstitution: Reconstitute with 0.5 ml sterile PBS containing 0.1% Bovine Serum Albumin. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For long term storage the addition of 0.09% sodium azide is recommended.

other info2 :

Immunogen: Recombinant human BMP-7. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to human BMP-7 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography. Target Species: Human

products description :

Rabbit anti Human BMP-7 antibody recognizes the disulphide-linked homodimeric cysteine knot protein known as human Bone Morphogenetic Protein 7 (BMP-7) or Osteogenic protein 1 (OP-1). BMP-7 is a member of the transforming growth factor beta (TGF-B) superfamily and one of a growing number of osteogenic proteins shown to induce bone and cartilage formation, and to play an important role in developmental processes, including cell proliferation, differentiation, apoptosis and morphogenesis. BMPs act through binding with a receptor complex consisting of type I and type II serine/threonine kinases, resulting ultimately in the activation of the Smad protein and mitogen-activated protein kinase (MAPK) signaling pathways. Several antagonist proteins, including, noggin, chordin, gremlin and follistatin, are responsible for modulating the signaling effects of BMPs, through the binding and blocking of receptor ligands, thereby preventing activation. Studies into the properties of BMP-7 have largely focused on its role during ontogeny of the kidney, owing to its prominent expression in the renal tubules. Results from research into experimental diabetic nephropathy have indicated that BMP-7 has antifibrogenic properties and appears to act as an antagonist to TGF-Beta (3-4).

ncbi gi num :

4502427

ncbi acc num :

NP_001710.1

ncbi gb acc num :

NM_001719.2

uniprot acc num :

P18075

ncbi mol weight :

49,313 Da

ncbi pathways :

ALK2 Signaling Events Pathway 137983!!BMP Receptor Signaling Pathway 137948!!BMP Signaling Pathway 1084755!!BMP Signaling Pathway 1108218!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Elastic Fibre Formation Pathway 730310!!Endochondral Ossification Pathway 198812!!Extracellular Matrix Organization Pathway 576262!!Hippo Signaling Pathway 749777

ncbi summary :

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008]

size :

0.05 mg

price :

555 USD