RABBIT ANTI HUMAN SDF-1 ALPHA:Biotin | MyBioSource MBS220218 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI HUMAN SDF-1 ALPHA:Biotin

catalog :

MBS220218

quantity :

0.05 mg

price :

540 USD

clonality :

polyclonal

host :

rabbit

conjugate :

biotin

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

product information

catalog number :

MBS220218

products type :

Antibody

products full name :

RABBIT ANTI HUMAN SDF-1 ALPHA:Biotin

products short name :

SDF-1 ALPHA

other names :

stromal cell-derived factor 1 isoform beta; Stromal cell-derived factor 1; stromal cell-derived factor 1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor; chemokine (C-X-C motif) ligand 12; C-X-C motif chemokine 12; Intercrine reduced in hepatomas; IRH; hIRH; Pre-B cell growth-stimulating factor; PBSF

products gene name :

SDF-1 ALPHA

other gene names :

CXCL12; CXCL12; IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12; SDF1; SDF1A; SDF1B; SDF-1; hSDF-1; IRH; hIRH; PBSF

uniprot entry name :

SDF1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

sequence length :

form :

Biotin. Purified IgG conjugated to Biotin - lyophilised

concentration :

IgG concentration 0.1 mg/ml after reconstitution

storage stability :

Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of reconstitution.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

ELISA: This biotinylated human SDF-1alpha antibody may be used in a direct ELISA or as the detection reagent in a sandwich ELISA with our purified human SDF-1alpha antibody as the capture reagent and recombinant human SDF-1alpha as the standard. Western Blot: This antibody may be used in Western Blotting under either reducing or non-reducing conditions with recombinant human SDF-1alpha as the positive control. ELISA: Minimum Dilution: 0.25; Maximum Dilution: 1.0ug/ml. Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml

other info1 :

Reconstitution: Reconstitute with 0.5ml sterile PBS containing 0.1% Bovine Serum Albumin. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For long term storage the addition of 0.09% sodium azide is recommended.

other info2 :

Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to human SDF-1 alpha were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography. Target Species: Human

products description :

Rabbit anti Human SDF-1 alpha antibody recognizes human SDF-1 alpha, otherwise known as CXCL12a, a 68 amino acid stromal cell derived CXC chemokine, which arises from alternative splicing of the SDF-1 gene. The two isoforms, SDF-1 alpha and SDF-1 beta, share an identical amino acid sequence, except for an additional four residues in the C-Terminal region of the beta isoform. SDF-1 binds with high-affinity to the G protein -coupled receptor CXCR4 (fusin) and acts as a chemoattractant for T and B lymphocytes, monocytes and migratory neurons, and is a vital factor in haematopoiesis and angiogenesis. By competitively binding to CXCR4, SDF-1 acts as an inhibitor for the CXCR4-mediated entry of HIV-1 virus into target T-cells, and the SDF-1-CXCR4 interaction is important for the regulation of trafficking of normal and malignant stem cells.

ncbi gi num :

10834988

ncbi acc num :

NP_000600.1

ncbi gb acc num :

NM_000609.6

uniprot acc num :

P48061

ncbi mol weight :

11,004 Da

ncbi pathways :

Axon Guidance Pathway 83065!!Axon Guidance Pathway 476!!CXCR4-mediated Signaling Events Pathway 137910!!Chemokine Receptors Bind Chemokines Pathway 106359!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664

ncbi summary :

This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

size :

0.05 mg

price :

540 USD