antibody

RABBIT ANTI CHICKEN INTERLEUKIN-1 BETA:Preservative Free

MBS220072

0.5 mg

550 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, enzyme immunoassay

Antibody

RABBIT ANTI CHICKEN INTERLEUKIN-1 BETA:Preservative Free

IL-1 BETA

interleukin-1 beta; interleukin-1 beta; IL-1 beta; interleukin 1, beta

IL1B; IL1beta; IL-1BETA

Polyclonal

IgG

Rabbit

267

This item recognizes chicken Interleukin 1 beta (chIL-1beta), which shares . homology with mammalian IL-1beta. IL-1 is a major regulator in both innate and adaptive immune responses, plays an important role in the regulation of acute inflammation and has also been implicated in many other processes, including both fever and fibrinogen induction. The previous names by which IL-1 has been known includes lymphocyte activating factor, endogenous pyrogen, catabolin, hemopoietin-1, melanoma growth inhibition factor, and osteoclast activating factor, reflecting its widespread cell expression. Studies using chicken models have indicated physiological similarities between chIL-1beta and mammalian IL-1beta in relation to its neural distribution and several factors have been shown to induce chIL-1beta secretion, including protein kinase C (PKC), Calmodulin-dependent protein kinase, lipopolysaccharide, phorbol esters, calcium and silica. This item neutralizes chicken IL-1 beta (1-2).

Preservative Free. Purified IgG - liquid

IgG concentration 0.5 mg/ml

Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

ELISA (EIA), Functional Assays (FN), Western Blot (WB)

Western Blot: This item detects a band of approximately 29kDa in HD-11 cell lysates transfected with chIL-1.

Immunogen: Recombinant chicken IL-1beta. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to chicken Interleukin-1beta were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography on protein G. Target Species: Chicken

MBS220072 recognizes chicken Interleukin 1 beta (chIL-1beta), which shares homology with mammalian IL-1beta. IL-1 is a major regulator in both innate and adaptive immune responses, plays an important role in the regulation of acute inflammation and has also been implicated in many other processes, including both fever and fibrinogen induction. The previous names by which IL-1 has been known includes lymphocyte activating factor, endogenous pyrogen, catabolin, hemopoietin-1, melanoma growth inhibition factor, and osteoclast activating factor, reflecting its widespread cell expression. Studies using chicken models have indicated physiological similarities between chIL-1beta and mammalian IL-1beta in relation to its neural distribution and several factors have been shown to induce chIL-1beta secretion, including protein kinase C (PKC), Calmodulin-dependent protein kinase, lipopolysaccharide, phorbol esters, calcium and silica. MBS220072 neutralizes chicken IL-1 beta (1-2).

45433514

NP_989855.1

NM_204524.1

Apoptosis Pathway (83966); Apoptosis Pathway (470); Cytokine-cytokine Receptor Interaction Pathway (119307); Cytokine-cytokine Receptor Interaction Pathway (460); Cytosolic DNA-sensing Pathway (125152); Cytosolic DNA-sensing Pathway (124833); Herpes Simplex Infection Pathway (377875); Herpes Simplex Infection Pathway (377865); Influenza A Pathway (217175); Influenza A Pathway (217150)

0.5 mg

550 USD