MOUSE ANTI HUMAN CALCITONIN RECEPTOR | MyBioSource MBS219841 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI HUMAN CALCITONIN RECEPTOR

catalog :

MBS219841

quantity :

0.1 mg

price :

570 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

30/7-9B4

reactivity :

human, cow

application :

western blot, ELISA, immunocytochemistry, flow cytometry, FACS, enzyme immunoassay

product information

catalog number :

MBS219841

products type :

Antibody

products full name :

MOUSE ANTI HUMAN CALCITONIN RECEPTOR

products short name :

CALCITONIN RECEPTOR

other names :

calcitonin receptor isoform 1; Calcitonin receptor; calcitonin receptor; calcitonin receptor

other gene names :

CALCR; CALCR; CRT; CTR; CT-R; CTR1; CT-R

uniprot entry name :

CALCR_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

30/7-9B4

host :

Mouse

reactivity :

Bovine, Rabbit

sequence length :

508

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

ELISA (EIA), Flow cytometry (FC/FACS), Immunofluorescence (IF), Immunohistology Paraffin*, Western Blot (WB)

app notes :

Immunohistology - Paraffin: Application Note: PLP fixation is recommended for optimal results.

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein G-Sepharose/dialysed against PBS from tissue culture supernatant.

other info2 :

Histology Positive Control Tissue: Human kidney. Target Species: Human

products description :

Mouse anti Human Calcitonin Receptor antibody, clone 30/7-9B4 recognizes the human calcitonin receptor, a 508 amino acid multi pass transmembrane membrane glycoprotein with seven transmembrane domains, coupled to G protein messenger systems. The calcitonin receptor is expressed in kidney, central and peripheral nervous systems and on osteoclasts. It is also expressed in a number of tissues during the development of the embryo and may be important in foetal morphogenesis.Clone MAb 9B4 recognises an epitope within the extra-cellular domain, the epitope is common to both C1a and C1b human isoforms. Calcitonin receptor expression is elevated in the inflammatory cells associated with diseased arteries and atherosclerotic plaques (Wookey et al. 2009) expression has also been noted within malignant cells of glioblastoma multiforme (Wookey et al. 2012).Several different isoforms of the calcitonin receptor, a result of alternative splicing and promotor usage have been identified. Mouse anti Human Calcitonin Receptor antibody, clone 30/7-9B4 was raised against the canonical isoform 1 but has been shown to bind to a truncated isoform lacking the N-terminal region of the receptor (Qi et al. 2012). The calcitonin receptor can associate with RAMP1, 2 and 3 to form discrete receptors for amylin Mouse anti human calcitonin receptor antibody, clone 30/7-9B4 has been successfully used for the demonstrating calcitonin receptor on human cryostat tissue section by immunohistochemistry and western blotting (Wookey et al. 2012).

ncbi gi num :

260064024

ncbi acc num :

NP_001158209.1

ncbi gb acc num :

NM_001164737.1

uniprot acc num :

P30988

ncbi mol weight :

32,423 Da

ncbi pathways :

Calcitonin-like Ligand Receptors Pathway 106379!!Class B/2 (Secretin Family Receptors) Pathway 106378!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664!!Disease Pathway 530764!!G Alpha (s) Signalling Events Pathway 119549!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020!!GPCRs, Class B Secretin-like Pathway 198781!!Metabolic Disorders Of Biological Oxidation Enzymes Pathway 1127637!!Neuroactive Ligand-receptor Interaction Pathway 83053

ncbi summary :

This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

size :

0.1 mg

price :

570 USD