MyBioSource

antibody

RAT ANTI MOUSE ABCA1

MBS219757

0.25 mg

310 USD

monoclonal

rat

mouse

FACS, flow cytometry, immunocytochemistry

MBS219757

Antibody

RAT ANTI MOUSE ABCA1

ABCA1

ATP-binding cassette sub-family A member 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette 1; ATP-binding cassette transporter 1; ATP-binding cassette, sub-family A (ABC1), member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1

ABCA1

Abca1; Abca1; Abc1; ABC-1; Abc1; ABC-1; ATP-binding cassette 1

ABCA1_MOUSE

Monoclonal

IgG2a

5A1-1422

Rat

2261

Purified. Purified IgG - liquid

IgG concentration 1.0mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

Flow cytometry (FC/FACS), Immunofluorescence (IF)

Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Flow Cytometry: Minimum Dilution: 1/10; Maximum Dilution: 1/200

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein G

Immunogen: ABCA1 transfected HeLa cells. Buffer Solution: Phosphate buffered saline. Target Species: Mouse

Rat anti Mouse ABCA1 antibody, clone 5A1-1422 recognizes murine adenosine triphosphate (ATP) Binding cassette transporter 1 (ABCA1). The ABC transporters are a large family of conserved proteins that transport a wide variety of molecules across cellular membranes. ABCA1 is a member of the ABC-A sub-family, which acts as a lipid translocator. The molecule was originally identified as a scavenger receptor on macrophages and research shows that ABCA1 also plays a major role in cholesterol metabolism. ABCA1 may play an important role in protecting against cardiovascular disease. Mutations in ABCA1 gene have been associated with Tangiers disease, a genetic disorder of lipid metabolism, and familial high density lipoprotein (HDL) deficiency.

90568038

NP_038482.3

NM_013454.3

P41233

253,912 Da

ABC Transporters Pathway 83232!!ABC Transporters Pathway 436!!Fat Digestion And Absorption Pathway 194386!!Fat Digestion And Absorption Pathway 194324!!Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway 1110842!!HDL-mediated Lipid Transport Pathway 1110839!!Lipid Digestion, Mobilization, And Transport Pathway 1110834!!Lipoprotein Metabolism Pathway 1110837!!Metabolism Pathway 1110796!!Metabolism Of Lipids And Lipoproteins Pathway 1110833

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]

0.25 mg

310 USD