MyBioSource

antibody

RAT ANTI MOUSE ABCA1:FITC

MBS219703

0.1 mg

235 USD

monoclonal

rat

FITC

mouse

FACS, flow cytometry

MBS219703

Antibody

RAT ANTI MOUSE ABCA1:FITC

ABCA1

ATP-binding cassette sub-family A member 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette 1; ATP-binding cassette transporter 1; ATP-binding cassette, sub-family A (ABC1), member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1

ABCA1

Abca1; Abca1; Abc1; ABC-1; Abc1; ABC-1; ATP-binding cassette 1

ABCA1_MOUSE

Monoclonal

IgG1

3A1-891.3

Rat

2261

FITC. Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid

IgG concentration 0.1mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

Flow cytometry (FC/FACS)

Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Flow Cytometry: Minimum Dilution: Neat; Maximum Dilution: 1/10

Perservative Stabilisers: 0.09% Sodium Azide (NaN3). 1% Bovine Serum Albumin. Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Immunogen: Syhthetic peptide corresponding to aa 215-233. Buffer Solution: Phosphate buffered saline. Target Species: Mouse

Rat anti Mouse ABCA1 antibody, clone 3A1-891.3 recognizes murine adenosine triphosphate (ATP) Binding cassette transporter 1 (ABCA1). The ABC transporters are a large family of conserved proteins that transport a wide variety of molecules across cellular membranes. ABCA1 is a member of the ABC-A sub-family, which acts as a lipid translocator. The molecule was originally identified as a scavenger receptor on macrophages and research shows that ABCA1 also plays a major role in cholesterol metabolism. ABCA1 may play an important role in protecting against cardiovascular disease. Mutations in ABCA1 gene have been associated with Tangiers disease, a genetic disorder of lipid metabolism, and familial high density lipoprotein (HDL) deficiency.

90568038

NP_038482.3

NM_013454.3

P41233

253,912 Da

ABC Transporters Pathway 83232!!ABC Transporters Pathway 436!!Fat Digestion And Absorption Pathway 194386!!Fat Digestion And Absorption Pathway 194324!!Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway 1110842!!HDL-mediated Lipid Transport Pathway 1110839!!Lipid Digestion, Mobilization, And Transport Pathway 1110834!!Lipoprotein Metabolism Pathway 1110837!!Metabolism Pathway 1110796!!Metabolism Of Lipids And Lipoproteins Pathway 1110833

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]

0.1 mg

235 USD