MOUSE ANTI HUMAN FOLLISTATIN 288 | MyBioSource MBS219673 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI HUMAN FOLLISTATIN 288

catalog :

MBS219673

quantity :

0.1 mg

price :

735 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

17/2

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

product information

catalog number :

MBS219673

products type :

Antibody

products full name :

MOUSE ANTI HUMAN FOLLISTATIN 288

products short name :

FOLLISTATIN 288

other names :

follistatin isoform FST317; Follistatin; follistatin; activin-binding protein; follistatin isoform FST317; follistatin; Activin-binding protein

other gene names :

FST; FST; FS; FS

uniprot entry name :

FST_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

17/2

host :

Mouse

sequence length :

317

specificity :

This item recognises human follistatin isoform 288 (FS288). Follistatin (FST) is a single-chain glycosylated protein of gonadal origin, originally identified as an antagonist of activin and suppressor of follicle stimulating hormone (FSH) synthesis/secretion. Alternative splicing of FST mRNA generates the two isoforms FS315 and FS288, the latter of which is the main cell-surface form and binds with high affinity to surface heparan sulphate proteoglycans, whilst FS315 binds with only low-affinity, and is considered to be the main circulating form of follistatin. As well as activin, FST interacts with other growth factors such as bone morphogenetic proteins (BMPs) -2, -4 and -7, myostatin, and growth differentiation factor 9 (GDF-9), playing a key role in cellular differentiation/proliferation, embryonic development and tissue repair. Clone 17/2 has been shown to exhibit 10% cross-reactivity with FS315 in an immunoassay.

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

ELISA (EIA), Immunohistology Paraffin*, Western Blot (WB)

app notes :

Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

other info2 :

Immunogen: Recombinant human FS288. Histology Positive Control Tissue: Testis. Fusion Partners: Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

MBS219673 recognises human follistatin isoform 288 (FS288). Follistatin (FST) is a single-chain glycosylated protein of gonadal origin, originally identified as an antagonist of activin and suppressor of follicle stimulating hormone (FSH) synthesis/secretion. Alternative splicing of FST mRNA generates the two isoforms FS315 and FS288, the latter of which is the main cell-surface form and binds with high affinity to surface heparan sulphate proteoglycans, whilst FS315 binds with only low-affinity, and is considered to be the main circulating form of follistatin. As well as activin, FST interacts with other growth factors such as bone morphogenetic proteins (BMPs) -2, -4 and -7, myostatin, and growth differentiation factor 9 (GDF-9), playing a key role in cellular differentiation/proliferation, embryonic development and tissue repair. Clone 17/2 has been shown to exhibit 10% cross-reactivity with FS315 in an immunoassay.

ncbi gi num :

5453652

ncbi acc num :

NP_006341.1

ncbi gb acc num :

NM_006350.3

uniprot acc num :

P19883

ncbi mol weight :

34,803 Da

ncbi pathways :

Antagonism Of Activin By Follistatin Pathway (730350); BMP Receptor Signaling Pathway (137948); Integrated Pancreatic Cancer Pathway (711360); Signal Transduction Pathway (477114); Signaling By Activin Pathway (730349); TGF Beta Signaling Pathway (198810); TGF-beta Signaling Pathway (83064); TGF-beta Signaling Pathway (475)

ncbi summary :

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]

uniprot summary :

FST: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 5q11.2. Cellular Component: cytoplasm; extracellular region; nucleus. Molecular Function: heparan sulfate proteoglycan binding; signal transducer activity; protein binding; activin binding. Biological Process: positive regulation of hair follicle development; BMP signaling pathway; negative regulation of activin receptor signaling pathway; negative regulation of cell differentiation; hair follicle morphogenesis; gamete generation; hemopoietic progenitor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; keratinocyte proliferation; skeletal development; pattern specification process; female gonad development; odontogenesis of dentine-containing teeth. Disease: Polycystic Ovary Syndrome 1

size1 :

0.1 mg

price1 :

735 USD